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How long does it take for Lucemyra (lofexidine) to work?

How quickly does Lucemyra work?

Medically reviewed by Last updated on Jul 20, 2020.

Official Answer


Lucemyra (lofexidine) works quickly to help reduce the symptoms of opioid withdrawal in adults who stop taking an opioid drug suddenly. After taking a single dose of Lucemyra, peak plasma concentration (the maximum level of the drug reached in the blood) is achieved 3-5 hours after Lucemyra is taken.

In clinical studies, Lucemyra started to work on the first day of use, providing some symptom relief. Importantly, the biggest improvement in opioid withdrawal symptom relief was experienced on day 2 and 3 of treatment, which is often when symptoms are most severe. Lucemyra also continued to reduce symptoms during the peak period of symptoms, which is generally the first 5 to 7 days after last opioid use.

The amount of time a person will experience opioid withdrawal systems varies and depends on the opioid drug being stopped. Symptoms of opioid withdrawal can appear within 8 hours of stopping a drug and can continue for 7 to 14 days or more for longer acting opioids.

Lucemyra is a central alpha-2 adrenergic agonist that works by reducing the release of norepinephrine. It is taken for up to 14 days, with the dose being gradually reduced over the late 2 to 4 days.


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