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What is the difference between Celexa and Lexapro?

Medically reviewed by Carmen Pope, BPharm. Last updated on Aug 15, 2024.

Official Answer by Drugs.com

Both Celexa and Lexapro belong to the class of medicines called selective serotonin reuptake inhibitors (SSRIs) and are FDA approved to treat depression.

The main differences between Celexa and Lexapro are:

Because both drugs are SSRIs, they have many similarities, such as:

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Why does Lexapro cause weight gain? Complete Patient Guide

Lexapro weight gain affects up 25 % to 41% of patients who take this antidepressant medication, although weight gain tends to be minimal, with an average gain of approximately 1 % to 3.7%. The weight gain associated with Lexapro occurs primarily due to the drug's mechanism of action on serotonin levels in the brain. When Lexapro blocks the serotonin transporter, it successfully increases serotonin availability to help treat depression and anxiety, but this same action can trigger unwanted changes in appetite and metabolism.

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When is the best time to take Lexapro? Morning vs Night Dosing

Lexapro (escitalopram) is usually taken once a day and can be taken either in the morning or at night.

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How long does it take for Lexapro to work?

Even though it takes Lexapro only a few hours to increase serotonin levels within the brain, it may take several weeks to start working. Signs that Lexapro has started working include an improvement in your sleep, energy, or appetite. In some, this may happen in as little as 1 to 2 weeks. Relief from symptoms, such as a depressed mood or a lack of interest in activities you used to enjoy, may take up to 6 to 8 weeks to fully improve. Continue reading

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