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Is diazoxide a vasodilator?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on June 16, 2025.

Official Answer by Drugs.com

Key Points

What is oral diazoxide?

The oral form of diazoxide (brand example: Proglycem) is used to treat low blood sugar (hypoglycemia) caused by certain cancers or other conditions that can make the pancreas release too much insulin. Oral diazoxide is for use in adults, children, infants, and newborns. You should not take oral diazoxide to treat occasional low blood sugar caused by diet.

Diazoxide raises blood sugar by slowing the release of insulin from the pancreas. The effect on lowering blood sugar begins within one hour and generally lasts no more than 8 hours in the presence of normal kidney function.

The most frequent and serious side effect with oral diazoxide is sodium (salt) and fluid retention and may result in congestive heart failure (CHF) in patients with heart problems. Using diuretic therapy can be helpful for this side effect.

Other frequently reported side effects of diazoxide include:

Related questions

How is oral diazoxide given?

Oral diazoxide is given as an oral suspension; the capsule form is no longer available.

Dosages are individualized and should be adjusted based on blood glucose needs. Doses are based on weight and divided into two or three equal doses every 8 or 12 hours. Special care should be taken to assure an accurate dose in infants and young children.

Patients should be under close observation by a health care provider. The clinical response and blood sugar (glucose) levels should be monitored closely until the patient has stabilized, usually several days.

If administration of oral diazoxide (brand example: Proglycem) is not effective after 2 to 3 weeks, the medicine should be discontinued.

Bottom Line

This is not all the information you need to know about oral or IV diazoxide for safe and effective use. Review the full diazoxide product information here, and discuss this information with your doctor or other health care provider.

References

Read next

What foods should I eat or avoid for hypoglycemia?

If you have diabetes, then you will know that certain foods can significantly affect your blood sugar levels. There is no one-size-fits-all meal plan for people with diabetes, but it can be confusing knowing what you can and can’t eat. Some examples of nutritionally high dinners suitable for people at risk of hypoglycemia include: soup, such as lentil and quinoa; grilled fish with broccoli, peas, and sweet potato; broccoli salad with artichokes, black beans, and sun-dried tomatoes; chicken vege stir fry with zucchini, carrots, and broccoli; and vegetarian lentil tacos. Continue reading

Can you have hypoglycemia without diabetes?

Yes, people without diabetes can have hypoglycemia, also called low blood sugar, but it is not very common. Hypoglycemia occurs most frequently in people with diabetes. Continue reading

What’s the difference between hypoglycemia and hyperglycemia?

Hypoglycemia means low blood sugar and is usually defined as a blood sugar less than 70 mg/dL. Hyperglycemia means high blood sugar and is usually defined as blood sugar greater than 125 mg/dL in a person who has not eaten in the last eight hours or more than 180 mg/dL in someone who ate two hours ago. Continue reading

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