Drug Interaction Report
1 drug interaction and 4 additional warnings found for the following 2 drugs:
- revefenacin
- trofinetide
Drug interactions
Moderate drug interactions
Moderate:revefenacin trofinetide
Applies to: revefenacin, trofinetide
Trofinetide may increase the blood levels of revefenacin following oral inhalation.
This may increase side effects such as:
- drowsiness
- blurred vision
- dry mouth
- heat intolerance
- flushing
- decreased sweating
- difficulty urinating
- abdominal cramping
- constipation
- rapid heart beat
- confusion
- memory problems
- glaucoma
Although serious side effects are not very common with inhaled products such as revefenacin because only limited amounts of the medication generally get absorbed into the bloodstream from the lungs, they can sometimes occur, especially in the elderly or when combined with medications that can impair its clearance from the body.
Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact.
You should avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how these medications affect you.
Also keep your eyes closed or use an eye mask during inhalation to avoid having the medication get into the eyes, which can cause blurry vision and eye pain as well as increase absorption of the medication into the bloodstream.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Disease interactions
4 potential interactionsApplies to: 4 conditions, including Urinary Retention, Liver Disease, Renal Dysfunction, and Glaucoma, Narrow Angle.
Glaucoma, Narrow Angle
Moderate:revefenacin
Revefenacin has a moderate potential interaction with Glaucoma, Narrow Angle.
Revefenacin should be used with caution in patients with narrow-angle glaucoma. Prescribers and patients should be alert for signs and symptoms of acute narrow-angle glaucoma (e.g. eye pain or discomfort, blurred vision, visual halos or colored images in association with red eyes from conjunctival congestion and corneal edema). Instruct patients to consult a physician immediately if any of these signs or symptoms develops.
Liver Disease
Moderate:revefenacin
Revefenacin has a moderate potential interaction with Liver Disease.
The systemic exposure of revefenacin is unchanged while that of its active metabolite is increased in subjects with moderate hepatic impairment. The safety of revefenacin has not been evaluated in COPD patients with mild-to-severe hepatic impairment, therefore revefenacin is not recommended in patients with any degree of hepatic impairment.
Renal Dysfunction
Moderate:revefenacin
Revefenacin has a moderate potential interaction with Renal Dysfunction.
No dosage adjustment is required in patients with renal impairment, however, patients with severe renal impairment should be monitored for systemic antimuscarinic side effects.
Urinary Retention
Moderate:revefenacin
Revefenacin has a moderate potential interaction with Urinary Retention.
Revefenacin should be used with caution in patients with urinary retention. Health care providers and patients should be alert for signs and symptoms of urinary retention (e.g. difficulty passing urine, painful urination), especially in patients with prostatic hyperplasia or bladder neck obstruction. Instruct patients to consult a healthcare provider immediately if any of these signs or symptoms develops.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.