Drug Interaction Report
6 potential interactions and/or warnings found for the following 2 drugs:
- midazolam
- Omeclamox-Pak (amoxicillin / clarithromycin / omeprazole)
Interactions between your drugs
clarithromycin midazolam
Applies to: Omeclamox-Pak (amoxicillin / clarithromycin / omeprazole), midazolam
Clarithromycin may significantly increase the blood levels of midazolam. This can increase the risk and/or severity of side effects including excessive drowsiness, motor impairment, amnesia, anxiety, hallucinations, and breathing difficulties (especially if you have a respiratory disorder such as asthma or obstructive sleep apnea). Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should avoid the use of alcohol while being treated with midazolam. Avoid driving or operating hazardous machinery until you know how the medication affects you, and do not exceed the dosage or frequency of use prescribed by your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
midazolam omeprazole
Applies to: midazolam, Omeclamox-Pak (amoxicillin / clarithromycin / omeprazole)
Omeprazole may increase the blood levels and effects of midazolam. This can increase the risk of side effects including excessive drowsiness and breathing difficulties. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
amoxicillin clarithromycin
Applies to: Omeclamox-Pak (amoxicillin / clarithromycin / omeprazole), Omeclamox-Pak (amoxicillin / clarithromycin / omeprazole)
Information for this minor interaction is available on the professional version.
clarithromycin omeprazole
Applies to: Omeclamox-Pak (amoxicillin / clarithromycin / omeprazole), Omeclamox-Pak (amoxicillin / clarithromycin / omeprazole)
Information for this minor interaction is available on the professional version.
Drug and food interactions
midazolam food
Applies to: midazolam
Grapefruit and grapefruit juice may interact with midazolam and lead to potentially dangerous side effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. Do not drink alcohol while taking midazolam. This medication can increase the effects of alcohol. You may feel more drowsy, dizzy, or tired if you take midazolam with alcohol. Talk to your doctor or pharmacist if you have any questions or concerns.
clarithromycin food
Applies to: Omeclamox-Pak (amoxicillin / clarithromycin / omeprazole)
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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