Accolate and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Accolate (zafirlukast).
Zafirlukast Food/Lifestyle
Moderate Food Interaction
ADJUST DOSING INTERVAL: Food may reduce the oral absorption and bioavailability of zafirlukast. In two separate studies, one using a high-fat and the other a high-protein meal, administration of zafirlukast with food reduced the mean bioavailability by approximately 40%.
MANAGEMENT: To ensure maximal oral absorption, zafirlukast should be administered at least 1 hour before or 2 hours after meals.
References (1)
- (2001) "Product Information. Accolate (zafirlukast)." Astra-Zeneca Pharmaceuticals
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Accolate drug interactions
There are 305 drug interactions with Accolate (zafirlukast).
Accolate disease interactions
There is 1 disease interaction with Accolate (zafirlukast) which include:
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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