Ranexa and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Ranexa (ranolazine).
Ranolazine Food/Lifestyle
Major Food Interaction
GENERALLY AVOID: Grapefruit and grapefruit juice may significantly increase the plasma concentrations of orally administered ranolazine. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit. Because ranolazine prolongs QT interval in a dose-dependent manner, high plasma levels of ranolazine may increase the risk of ventricular arrhythmias such as ventricular tachycardia, ventricular fibrillation, and torsade de pointes.
MANAGEMENT: Patients treated with ranolazine should avoid consumption of grapefruit juice and other grapefruit products if possible. Otherwise, the dosage of ranolazine should be limited to 500 mg twice a day.
References (1)
- (2006) "Product Information. Ranexa (ranolazine)." Calmoseptine Inc
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Ranexa drug interactions
There are 554 drug interactions with Ranexa (ranolazine).
Ranexa disease interactions
There are 3 disease interactions with Ranexa (ranolazine) which include:
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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