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Pemoline and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with pemoline.

Major

Pemoline High Blood Pressure (Hypertension)

Major Potential Hazard, Moderate plausibility

CNS stimulants - cardiac disease

Many CNS stimulants are contraindicated in patients with significant cardiovascular impairment such as uncompensated heart failure, severe coronary disease, severe hypertension (including that associated with hyperthyroidism or pheochromocytoma), cardiac structural abnormalities, serious arrhythmias, etc. Sudden death has been reported in patients with structural cardiac abnormalities or other serious cardiac disease who are treated with CNS stimulants at the recommended dosages for attention deficit hyperactivity disorder; use of these agents should be avoided in patients with known structural cardiac abnormalities, cardiomyopathy, serious cardiac arrhythmia, coronary artery disease, or other serious cardiac disease. Additionally, stroke, myocardial infarction, chest pain, syncope, arrhythmias, and other symptoms have been reported in adults under treatment. A careful assessment of the cardiovascular status should be done in patients being considered for treatment. This includes family history, physical exam, and further cardiac evaluation (EKG and echocardiogram). Patients who develop symptoms should have a detailed cardiac evaluation and if needed, treatment should be suspended.

References

  1. (2001) "Product Information. Provigil (modafinil)." Cephalon, Inc
  2. (2001) "Product Information. Dopram (doxapram)." West Ward Pharmaceutical Corporation
  3. (2001) "Product Information. Dexedrine (dextroamphetamine)." SmithKline Beecham
  4. (2001) "Product Information. Didrex (benzphetamine)." Pharmacia and Upjohn
  5. (2001) "Product Information. Tenuate (diethylpropion)." Aventis Pharmaceuticals
  6. (2001) "Product Information. Focalin (dexmethylphenidate)." Mikart Inc
  7. (2002) "Product Information. Concerta (methylphenidate)." Alza
  8. (2002) "Product Information. Strattera (atomoxetine)." Lilly, Eli and Company
  9. (2007) "Product Information. Vyvanse (lisdexamfetamine)." Shire US Inc
  10. (2007) "Product Information. Nuvigil (armodafinil)." Cephalon Inc
  11. (2012) "Product Information. Phendimetrazine Tartrate SR (phendimetrazine)." Sandoz Inc
  12. (2019) "Product Information. Phentermine Hydrochloride (phentermine)." Tagi Pharma Inc
  13. (2023) "Product Information. Desoxyn (methamphetamine)." Recordati Rare Diseases Inc, SUPPL-38
View all 13 references
Major

Pemoline High Blood Pressure (Hypertension)

Major Potential Hazard, Moderate plausibility

CNS stimulants - hypertension

CNS stimulants increase blood pressure and heart rate; the use of some agents may be contraindicated in patients with severe/uncontrolled hypertension. Caution should be used when administering to patients with preexisting high blood pressure (even mild hypertension) and other cardiovascular conditions. All patients under treatment should be regularly monitored for potential tachycardia and hypertension.

References

  1. (2001) "Product Information. Provigil (modafinil)." Cephalon, Inc
  2. (2001) "Product Information. Dopram (doxapram)." West Ward Pharmaceutical Corporation
  3. (2001) "Product Information. Dexedrine (dextroamphetamine)." SmithKline Beecham
  4. (2001) "Product Information. Didrex (benzphetamine)." Pharmacia and Upjohn
  5. (2001) "Product Information. Tenuate (diethylpropion)." Aventis Pharmaceuticals
  6. (2001) "Product Information. Focalin (dexmethylphenidate)." Mikart Inc
  7. (2002) "Product Information. Concerta (methylphenidate)." Alza
  8. (2002) "Product Information. Strattera (atomoxetine)." Lilly, Eli and Company
  9. (2007) "Product Information. Vyvanse (lisdexamfetamine)." Shire US Inc
  10. (2007) "Product Information. Nuvigil (armodafinil)." Cephalon Inc
  11. (2012) "Product Information. Phendimetrazine Tartrate SR (phendimetrazine)." Sandoz Inc
  12. (2019) "Product Information. Phentermine Hydrochloride (phentermine)." Tagi Pharma Inc
  13. (2023) "Product Information. Desoxyn (methamphetamine)." Recordati Rare Diseases Inc, SUPPL-38
View all 13 references

Pemoline drug interactions

There are 106 drug interactions with pemoline.

Pemoline disease interactions

There are 11 disease interactions with pemoline which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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