Pemoline and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with pemoline.
Pemoline High Blood Pressure (Hypertension)
Major Potential Hazard, Moderate plausibility
CNS stimulants - cardiac disease
Many CNS stimulants are contraindicated in patients with significant cardiovascular impairment such as uncompensated heart failure, severe coronary disease, severe hypertension (including that associated with hyperthyroidism or pheochromocytoma), cardiac structural abnormalities, serious arrhythmias, etc. Sudden death has been reported in patients with structural cardiac abnormalities or other serious cardiac disease who are treated with CNS stimulants at the recommended dosages for attention deficit hyperactivity disorder; use of these agents should be avoided in patients with known structural cardiac abnormalities, cardiomyopathy, serious cardiac arrhythmia, coronary artery disease, or other serious cardiac disease. Additionally, stroke, myocardial infarction, chest pain, syncope, arrhythmias, and other symptoms have been reported in adults under treatment. A careful assessment of the cardiovascular status should be done in patients being considered for treatment. This includes family history, physical exam, and further cardiac evaluation (EKG and echocardiogram). Patients who develop symptoms should have a detailed cardiac evaluation and if needed, treatment should be suspended.
Pemoline High Blood Pressure (Hypertension)
Major Potential Hazard, Moderate plausibility
CNS stimulants - hypertension
CNS stimulants increase blood pressure and heart rate; the use of some agents may be contraindicated in patients with severe/uncontrolled hypertension. Caution should be used when administering to patients with preexisting high blood pressure (even mild hypertension) and other cardiovascular conditions. All patients under treatment should be regularly monitored for potential tachycardia and hypertension.
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Pemoline drug interactions
There are 109 drug interactions with pemoline.
Pemoline disease interactions
There are 11 disease interactions with pemoline which include:
- agitation
- cardiac disease
- hypertension
- psychiatric disorders
- substance abuse
- tics
- liver disease
- renal dysfunction
- liver disease
- renal dysfunction
- seizure disorders
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More about pemoline
- pemoline consumer information
- Check interactions
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- Reviews (19)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: CNS stimulants
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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