Mirtazapine and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with mirtazapine.
Mirtazapine Food/Lifestyle
Moderate Food Interaction
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
References (4)
- Warrington SJ, Ankier SI, Turner P (1986) "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology, 15, p. 31-7
- Gilman AG, eds., Nies AS, Rall TW, Taylor P (1990) "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc.
- (2012) "Product Information. Fycompa (perampanel)." Eisai Inc
- (2015) "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc
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Mirtazapine High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Moderate Potential Hazard, Moderate plausibility
mirtazapine - hyperlipidemia
Mirtazapine may significantly elevate serum triglyceride and total cholesterol levels. Patients with preexisting hyperlipidemia may require closer monitoring during mirtazapine therapy, and adjustments made accordingly in their lipid-lowering regimen.
References (4)
- Smith WT, Glaudin V, Panagides J, Gilvary E (1990) "Mirtazapine vs. amitriptyline vs. placebo in the treatment of major depressive disorder." Psychopharmacol Bull, 26, p. 191-6
- (2001) "Product Information. Remeron (mirtazapine)." Organon
- Davis R, Wilde MI (1996) "Mirtazapine: a review of its pharmacology and therapeutic potential in the management of major depression." Cns Drugs, 5, p. 389-402
- Montgomery SA (1995) "Safety of mirtazapine: a review." Int Clin Psychopharmacol, 10(suppl 4, p. 37-45
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Mirtazapine drug interactions
There are 671 drug interactions with mirtazapine.
Mirtazapine disease interactions
There are 13 disease interactions with mirtazapine which include:
- renal/liver disease
- pheochromocytoma
- bipolar screening
- depression
- hypotension
- neutropenia
- mania
- ALT elevations
- hyperlipidemia
- hyponatremia
- mania/hypomania
- seizures
- glaucoma
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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