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Mirtazapine and Alcohol / Food Interactions

There are 2 alcohol/food/lifestyle interactions with mirtazapine which include:


mirtazapine ↔ food

Moderate Food Interaction

Alcohol can increase the nervous system side effects of mirtazapine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with mirtazapine. Do not use more than the recommended dose of mirtazapine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)

Moderate Potential Hazard, Moderate plausibility

mirtazapine - hyperlipidemia

Mirtazapine may significantly elevate serum triglyceride and total cholesterol levels. Patients with preexisting hyperlipidemia may require closer monitoring during mirtazapine therapy, and adjustments made accordingly in their lipid-lowering regimen.


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  2. Davis R, Wilde MI "Mirtazapine: a review of its pharmacology and therapeutic potential in the management of major depression." Cns Drugs 5 (1996): 389-402
  3. Montgomery SA "Safety of mirtazapine: a review." Int Clin Psychopharmacol 10(suppl 4 (1995): 37-45
  4. Smith WT, Glaudin V, Panagides J, Gilvary E "Mirtazapine vs. amitriptyline vs. placebo in the treatment of major depressive disorder." Psychopharmacol Bull 26 (1990): 191-6
View all 4 references

Mirtazapine drug interactions

There are 1052 drug interactions with mirtazapine

Mirtazapine disease interactions

There are 13 disease interactions with mirtazapine which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.