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Metozolv ODT and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with Metozolv ODT (metoclopramide).

Moderate

Metoclopramide Food

Moderate Food Interaction

GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.

MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

References (4)
  1. Warrington SJ, Ankier SI, Turner P (1986) "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology, 15, p. 31-7
  2. Gilman AG, eds., Nies AS, Rall TW, Taylor P (1990) "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc.
  3. (2012) "Product Information. Fycompa (perampanel)." Eisai Inc
  4. (2015) "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc

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Moderate

Metoclopramide High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

metoclopramide - hypertension

In a study involving patients with essential hypertension, intravenously administered metoclopramide was shown to induce the release of catecholamines. Therapy with metoclopramide should be administered cautiously in patients with hypertension because of potential increases in blood pressure.

References (2)
  1. Filibeck DJ, Grimm D, Forman WB, Leidner BA (1984) "Metoclopramide-induced hypertensive crisis." Clin Pharm, 3, p. 548-9
  2. (2001) "Product Information. Reglan (metoclopramide)." Wyeth-Ayerst Laboratories

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Metozolv ODT drug interactions

There are 363 drug interactions with Metozolv ODT (metoclopramide).

Metozolv ODT disease interactions

There are 10 disease interactions with Metozolv ODT (metoclopramide) which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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