Pepcid AC Maximum Strength and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Pepcid AC Maximum Strength (famotidine).
Famotidine Nicotine
Minor Drug Interaction
H2 antagonists may reduce the clearance of nicotine. Cimetidine, 600 mg given twice a day for two days, reduced clearance of an intravenous nicotine dose by 30%. Ranitidine, 300 mg given twice a day for two days, reduced clearance by 10%. The clinical significance of this interaction is not known. Patients should be monitored for increased nicotine effects when using the patches or gum for smoking cessation and dosage adjustments should be made as appropriate.
References (1)
- Bendayan R, Sullivan JT, Shaw C, Frecker RC, Sellers EM (1990) "Effect of cimetidine and ranitidine on the hepatic and renal elimination of nicotine in humans." Eur J Clin Pharmacol, 38, p. 165-9
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Pepcid AC Maximum Strength drug interactions
There are 314 drug interactions with Pepcid AC Maximum Strength (famotidine).
Pepcid AC Maximum Strength disease interactions
There are 2 disease interactions with Pepcid AC Maximum Strength (famotidine) which include:
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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