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Diazepam and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with diazepam.


diazePAM food

Moderate Food Interaction

Grapefruit and grapefruit juice may interact with diazePAM and lead to potentially dangerous side effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. Do not drink alcohol while taking diazePAM. This medication can increase the effects of alcohol. You may feel more drowsy, dizzy, or tired if you take diazePAM with alcohol. Talk to your doctor or pharmacist if you have any questions or concerns.

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Moderate Potential Hazard, High plausibility

benzodiazepines - obesity

The plasma half-lives of benzodiazepines may be prolonged in obese patients, presumably due to increased distribution into fat. Marked increases in distribution (> 100%) have been reported for diazepam and midazolam, and moderate increases (25% to 100%) for alprazolam, lorazepam, and oxazepam. Therapy with benzodiazepines should be administered cautiously in obese patients, with careful monitoring of CNS status. Longer dosing intervals may be appropriate. When dosing by weight, loading doses should be based on actual body weight, while maintenance dose should be based on ideal body weight to avoid toxicity.


  1. "Product Information. Xanax (alprazolam)." Pharmacia and Upjohn PROD (2002):
  2. "Product Information. Valium (diazepam)." Roche Laboratories PROD (2002):
  3. "Product Information. Ativan (lorazepam)." Wyeth-Ayerst Laboratories PROD (2002):
  4. "Product Information. Serax (oxazepam)." Wyeth-Ayerst Laboratories PROD (2001):
  5. "Product Information. Restoril (temazepam)." Sandoz Pharmaceuticals Corporation PROD (2001):
  6. "Product Information. Halcion (triazolam)." Pharmacia and Upjohn PROD (2001):
  7. "Product Information. Dalmane (flurazepam)." Roche Laboratories PROD (2001):
  8. "Product Information. Tranxene (clorazepate)." Abbott Pharmaceutical PROD (2001):
  9. "Product Information. Klonopin (clonazepam)." Roche Laboratories PROD (2001):
  10. "Product Information. Prosom (estazolam)." Abbott Pharmaceutical (2022):
  11. "Product Information. Librium (chlordiazepoxide)." Roche Laboratories PROD (2001):
  12. "Product Information. Doral (quazepam)." Wallace Laboratories PROD (2001):
  13. "Product Information. Versed (midazolam)." Roche Laboratories PROD (2001):
  14. American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
View all 14 references

Diazepam drug interactions

There are 521 drug interactions with diazepam.

Diazepam disease interactions

There are 12 disease interactions with diazepam which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.