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Cloxacillin and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with cloxacillin.


Cloxacillin Food

Moderate Food Interaction

You may experience reduced absorption of cloxacillin in the presence of food. The effectiveness of the antibiotic may be reduced. Cloxacillin should be administered one hour before or two hours after meals. This will make it easier for your body to absorb the medication. Penicillin V and amoxicillin are not affected by food and may be given without regard to meals.

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Cloxacillin High Blood Pressure (Hypertension)

Moderate Potential Hazard, High plausibility

cloxacillin - sodium

Each 250 mg capsule of cloxacillin sodium contains approximately 14 mg (0.6 mEq) of sodium, and each teaspoonful of the 125 mg/5 mL oral solution contains approximately 11 mg (0.48 mEq) of sodium. The sodium content should be considered in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.


  1. (2002) "Product Information. Tegopen (cloxacillin)." Apothecon Inc

Cloxacillin drug interactions

There are 40 drug interactions with cloxacillin.

Cloxacillin disease interactions

There are 3 disease interactions with cloxacillin which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.