Duavee and Alcohol/Food Interactions
There are 5 alcohol/food/lifestyle interactions with Duavee (bazedoxifene / conjugated estrogens).
Conjugated Estrogens Food
Minor Food Interaction
Information for this minor interaction is available on the professional version.
Switch to professional interaction data
Bazedoxifene High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Major Potential Hazard, Moderate plausibility
bazedoxifene - CV disorders
The use of bazedoxifene, alone or in combination is known to increase the risk of venous thromboembolism (VTE). Bazedoxifene is contraindicated in women with active DVT, pulmonary embolism, active arterial thromboembolic disease (such as stroke or myocardial infarctions), or a history of any of these conditions. Other risk factors for cardiovascular disorders and/or venous thromboembolism such as hypertension, diabetes, smoking, hypercholesterolemia, obesity, lupus erythematosus (in personal or family history), should be evaluated and managed appropriately.
Bazedoxifene Obesity
Major Potential Hazard, Moderate plausibility
bazedoxifene - CV disorders
The use of bazedoxifene, alone or in combination is known to increase the risk of venous thromboembolism (VTE). Bazedoxifene is contraindicated in women with active DVT, pulmonary embolism, active arterial thromboembolic disease (such as stroke or myocardial infarctions), or a history of any of these conditions. Other risk factors for cardiovascular disorders and/or venous thromboembolism such as hypertension, diabetes, smoking, hypercholesterolemia, obesity, lupus erythematosus (in personal or family history), should be evaluated and managed appropriately.
Conjugated Estrogens High Blood Pressure (Hypertension)
Major Potential Hazard, High plausibility
estrogens - hypertension
The risk of myocardial infarction and strokes, including those associated with oral contraceptive use and some estrogen use, is increased in patients with hypertension. Moreover, estrogens (and progestogens) may elevate blood pressure and worsen the hypertension, thus compounding the risk. Clinically significant blood pressure increases have been reported during estrogen therapy, particularly in patients receiving high dosages or treated with oral contraceptive combinations having high progestational activity. These effects also increase with duration of therapy and patient age. Therapy with estrogens should be administered cautiously in patients with preexisting hypertension. Patients should be monitored for changes in cardiovascular status, and their antihypertensive regimen adjusted or estrogen therapy withdrawn as necessary. In patients requiring contraception, alternative methods should be considered for those who are hypertensive, over age 35, and smoke.
Conjugated Estrogens High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Moderate Potential Hazard, Moderate plausibility
estrogens - hyperlipidemia
Although estrogens have generally favorable effects on plasma lipids, including increases in HDL and decreases in total cholesterol and LDL, they have also been associated with significant elevations in triglyceride levels, particularly when high dosages are used. Severe hyperlipidemia is known to sometimes cause pancreatitis. Patients with preexisting hyperlipidemia may require closer monitoring during estrogen therapy, and adjustments made accordingly in their lipid-lowering regimen.
Switch to professional interaction data
Duavee drug interactions
There are 265 drug interactions with Duavee (bazedoxifene / conjugated estrogens).
Duavee disease interactions
There are 23 disease interactions with Duavee (bazedoxifene / conjugated estrogens) which include:
- abnormal vaginal bleeding
- breast cancer
- CV disorders
- hepatic impairment
- abnormal vaginal bleeding
- carcinomas (estrogenic)
- hypercalcemia in breast cancer
- hypertension
- thromboembolism/cardiovascular
- hepatic neoplasms
- hypothyroidism
- renal dysfunction
- angioedema
- gallbladder disease
- hypercalcemia
- hyperlipidemia
- liver disease
- melasma
- depression
- fluid retention
- glucose intolerance
- retinal thrombosis
- thyroid function tests
More about Duavee (bazedoxifene / conjugated estrogens)
- Duavee consumer information
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (33)
- Imprints, shape & color data
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- FDA approval history
- Drug class: sex hormone combinations
- En español
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.