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Piperacillin Tazobactam Injection

Last Updated: February 7, 2018
Status: Current

Piperacillin Tazobactam Injection

Products Affected - Description
  • Zosyn solution for injection, Baxter
    3.375 gram, 50 mL frozen premixed bag, 24 count (NDC 00206-8861-02)

 
Zosyn powder for solution for injection, Pfizer
2.25 gram, vial, 10 count (NDC 00206-8852-16)
3.375 gram, vial, 10 count (NDC 00206-8854-16)
4.5 gram, vial, 10 count (NDC 00206-8855-16)
40.5 gram, bulk vial, 1 count (NDC 00206-8859-10) 
 
Piperacillin and Tazobactam powder for solution for injection, Apotex
3.375 gram vial, 10 count (NDC 60505-0687-04)

Piperacillin and Tazobactam powder for solution for injection, Mylan Institutional
3.375 gram, vial, 10 count (NDC 67457-0522-37)
4.5 gram, vial, 10 count (NDC 67457-0523-45)
 
Piperacillin and Tazobactam powder for solution for injection, Pfizer
3.375 gram, ADD-Vantage vial, 10 count (NDC 00409-3378-13)
4.5 gram, ADD-Vantage vial, 10 count (NDC 00409-3379-04)
 
Piperacillin and Tazobactam powder for solution for injection, Sandoz
2.25 gram, vial, 10 count (NDC 00781-3110-95) - discontinued
4.5 gram, vial, 10 count (NDC 00781-3367-95) - discontinued
 
Piperacillin and Tazobactam powder for solution for injection, WG Critical Care
40.5 gram, bulk vial, 1 count (NDC 44567-0804-01)
Reason for the Shortage
    • Apotex has piperacillin/tazobactam on shortage due to regulatory delays.
    • AuroMedics and Sandoz could not provide a reason for the shortage.
    • Fresenius Kabi has piperacillin/tazobactam on shortage due to increased demand.
    • Mylan Institutional launched piperacillin/tazobactam 3.375 gram and 4.5 gram vials in early-June 2016.
    • Pfizer has Zosyn single dose vials and piperacillin/tazobactam on shortage due to manufacturing delays.
    • Sagent has piperacillin/tazobactam on shortage due to increased demand.
    • Sandoz has piperacillin/tazobactam available for contracted customers.
    • WG Critical Care states the reason for the shortage is increased demand.
    • FDA in conjunction with SteriMax was allowing temporary importation of piperacillin/tazobactam 3.375 gram, 4.5 gram, and 40.5 gram vials from Canada. This was being distributed through X-Gen Pharmaceuticals. These are no longer being imported with the launch of the products from X-Gen. The product codes on these items will not be recognized by U.S. systems so institutions will need to implement alternative plans to assure the dose is being given correctly. More information can be found here on the FDA site.
    • Wockhardt has piperacillin/tazobactam injection available.
    • X-Gen has piperacillin/tazobactam injection available.
Available Products
  • Zosyn solution for injection, Baxter
    2.25 gram, 50 mL frozen premixed bag, 24 count (NDC 00206-8860-02)
    4.5 gram, 50 mL frozen premixed bag, 12 count (NDC 00206-8862-02)

 
Piperacillin and Tazobactam powder for solution for injection, Apotex
2.25 gram, vial, 10 count (NDC 60505-0686-04)
4.5 gram, vial, 10 count (NDC 60505-0688-04)
40.5 gram, bulk vial, 1 count (NDC 60505-0773-00)
 
Piperacillin and Tazobactam powder for solution for injection, AuroMedics
2.25 gram, vial, 10 count (NDC 55150-0119-30)
3.375 gram, vial, 10 count (NDC 55150-0120-30)
4.5 gram, vial, 10 count (NDC 55150-0121-50)
 
Piperacillin and Tazobactam powder for solution for injection, Fresenius Kabi
2.25 gram, vial, 10 count (NDC 63323-0309-20)
3.375 gram, vial, 10 count (NDC 63323-0300-30)
4.5 gram, vial, 10 count (NDC 63323-0320-50)
40.5 gram, bulk vial, 1 count (NDC 63323-0304-74)
 
Piperacillin and Tazobactam powder for solution for injection, Pfizer
2.25 gram, ADD-Vantage vial, 10 count (NDC 00409-3374-02)
2.25 gram, vial, 10 count (NDC 00409-3383-02)
3.375 gram, vial, 10 count (NDC 00409-3385-13)
4.5 gram, vial, 10 count (NDC 00409-3390-04)
 
Piperacillin and Tazobactam powder for solution for injection, Sagent
2.25 gram, vial, 10 count (NDC 25021-0164-30)
3.375 gram, vial, 10 count (NDC 25021-0165-30)
4.5 gram, vial, 10 count (NDC 25021-0166-48)
 
Piperacillin and Tazobactam powder for solution for injection, Sandoz
2.25 gram, vial, 10 count (NDC 00781-3344-95)
3.375 gram, vial, 10 count (NDC 00781-3113-95)
3.375 gram, vial, 10 count (NDC 00781-3350-95)
4.5 gram, vial, 10 count (NDC 00781-3367-95) - discontinued
4.5 gram, vial, 10 count (NDC 00781-3114-95)
 
Piperacillin and Tazobactam powder for solution for injection, WG Critical Care
2.25 gram, vial, 10 count (NDC 44567-0801-10)
3.375 gram, vial, 10 count (NDC 44567-0802-10)
4.5 gram, vial, 10 count (NDC 44567-0803-10)
 
Piperacillin and Tazobactam powder for solution for injection, Wockhardt USA
2.25 gram, vial, 10 count (NDC 64679-0034-01)
3.375 gram, vial, 10 count (NDC 64679-0056-01)
4.5 gram, vial, 10 count (NDC 64679-0012-01)
40.5 gram, vial, 10 count (NDC 64679-0679-01)
 
Piperacillin and Tazobactam powder for solution for injection, X-Gen
2.25 gram, vial, 10 count (NDC 39822-0123-02)
3.375 gram, vial, 10 count (NDC 39822-0125-04)
4.5 gram, vial, 10 count (NDC 39822-0127-06)
40.5 gram, vial, 1 count (NDC 39822-0139-07)

Estimated Resupply Dates

    • Apotex has piperacillin/tazobactam 3.375 gram and 40.5 gram vials on back order and the company cannot estimate a release date.
    • Baxter has Zosyn 3.375 gram/50 mL premixed bags available in limited supply.
    • Mylan has piperacillin/tazobactam 3.375 gram vials available with a short expiration date (expiration September 2018). The 4.5 gram vials are on back order and the company cannot estimate a release date.
    • Pfizer has Zosyn 2.25 gram vials, 3.375 gram vials, 4.5 gram vials, and 40.5 gram vials on back order and the company estimates a release date of 2019. Pfizer has piperacillin/tazobactam 3.375 gram and 4.5 gram ADD-Vantage vials available in limited supply.
    • WG Critical Care has piperacillin/tazobactam 40.5 gram vials on back order and the company estimates a release date in April 2018.

Updated

February 7, January 11, 2018; December 7, October 5, September 22, August 15 and 4, July 10, June 27, 20, 12, 6 and 2, May 5, April 3, March 24, 13 and 10, February 24, January 6, 2017; December 20, 19 and 5, November 29, 15 and 6, September 27 and 9, August 11, July 29 and 7, June 27, 16, 13 and 7, May 26 and 12, April 29, 25 and 6, March 7 and 1, February 26 and 4, January 6, 2016; December 22 and 17, November 20, 9 and 3, October 19, 12 and 6, September 14 and 3, August 6, July 14, June 5, May 27 and 11, April 30, 16 and 10, March 25, 13 and 3, February 25, January 26 and 9, 2015; December 22, 18, 16 and 3, November 25, 17 and 7, October 24 and 8, September 22 and 3, August 19, 7 and 6, July 17 and 2, May 14 and 5, April 23, March 31, 28, 12 and 5, 2014, University of Utah, Drug Information Service. Copyright 2017, Drug Information Service, University of Utah, Salt Lake City, UT.

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