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Piperacillin / tazobactam Pregnancy and Breastfeeding Warnings

Piperacillin / tazobactam is also known as: Zosyn

Piperacillin / tazobactam Pregnancy Warnings

Piperacillin-tazobactam has been assigned to pregnancy category B by the FDA. Animal studies have failed to reveal evidence of fetal toxicity or teratogenicity. There are no controlled data in human pregnancies. Piperacillin-tazobactam should only be given during pregnancy when need has been clearly established.

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Piperacillin / tazobactam Breastfeeding Warnings

Piperacillin is excreted into human milk in small amounts. There are no data on the excretion of tazobactam into human milk. The manufacturer recommends that caution be used when administering piperacillin-tazobactam to nursing women.

See references

References for pregnancy information

  1. Bourget P, Sertin A, LesneHulin A, Fernandez H, Ville Y, VanPeborgh P "Influence of pregnancy on the pharmacokinetic behaviour and the trans-placental transfer of the piperacillin-tazobactam combination." Eur J Obstet Gynecol Reprod Biol 76 (1998): 21-7
  2. "Product Information. Zosyn (piperacillin-tazobactam)." Lederle Laboratories, Wayne, NJ.

References for breastfeeding information

  1. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL:" ([cited 2013 -]):
  2. "Product Information. Zosyn (piperacillin-tazobactam)." Lederle Laboratories, Wayne, NJ.

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