Generic Name: piperacillin and tazobactam (PI per a SIL in and TAZ oh BAK tam)
Brand Names: Zosyn
Medically reviewed on August 9, 2018
What is Zosyn?
Zosyn is used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, severe vaginal infections, stomach infections, skin infections, and pneumonia.
Zosyn is sometimes given together with other antibiotics.
You should not use Zosyn if you have ever had an allergic reaction to certain antibiotics (especially a penicillin or cephalosporin antibiotic).
Before using Zosyn tell your doctor if you have kidney disease, a bleeding or blood clotting disorder, low levels of potassium in your blood, cystic fibrosis, a history of allergies, if you are on a low-salt diet, or if you are allergic to a cephalosporin antibiotic such as cefdinir (Omnicef), cefprozil (Cefzil), cefuroxime (Ceftin), cephalexin (Keflex), and others.
Use Zosyn for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Piperacillin and tazobactam will not treat a viral infection such as the common cold or flu.
Zosyn may cause bleeding, especially in people with kidney disease or using certain medicines. Tell your doctor if you are using any medication to prevent blood clots such as alteplase (Activase), bivalirudin (Angiomax), clopidogrel (Plavix), dabigatran (Pradaxa), dipyridamole (Persantine, Aggrenox), enoxaparin (Lovenox), fondaparinux (Arixtra), heparin, tenecteplase (TNKase), ticlopidine (Ticlid), tinzaparin (Innohep), warfarin (Coumadin, Jantoven), and others.
Before taking this medicine
You should not use Zosyn if you are allergic to:
piperacillin or any other penicillin antibiotic (amoxicillin, ampicillin, Augmentin, dicloxacillin, oxacillin, penicillin, ticarcillin, or others);
a cephalosporin antibiotic such as cefdinir (Omnicef), cefprozil (Cefzil), cefuroxime (Ceftin), cephalexin (Keflex), or others.
To make sure Zosyn is safe for you, tell your doctor if you have ever had:
kidney disease (or if you are on dialysis);
a bleeding or blood clotting disorder;
an electrolyte imbalance such as low levels of potassium in your blood;
any type of allergy; or
if you are on a low-salt diet.
It is not known whether Zosyn will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Piperacillin and tazobactam can pass into breast milk, but effects on the nursing baby are not known. Tell your doctor if you are breast-feeding a baby while using Zosyn.
How should I use Zosyn?
Zosyn is injected into a vein through an IV. You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.
Zosyn is a powder medicine that must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.
Prepare your dose only when you are ready to give an injection. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.
Use Zosyn for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. This medicine will not treat a viral infection such as the common cold or flu.
While using Zosyn, you may need frequent blood tests.
This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using Zosyn.
Each single-use vial (bottle) of Zosyn is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.
Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.
Store the unmixed Zosyn powder and the liquid diluent at cool room temperature, away from moisture and heat. Do not freeze the vial.
Medicine mixed in an IV bag must be used within 24 hours if you keep it at room temperature.
Medicine mixed in a syringe can be stored in a refrigerator for up to 48 hours. Mixed medication in an IV bag can also be stored in the refrigerator for up to 7 days. Do not freeze. Throw away any unused mixture that has not been used within these times.
Mixed medicine in an infusion pump must be used within 12 hours if you keep it at room temperature.
If your medicine is frozen when you receive it, store the medicine container in a freezer until you are ready to prepare your dose.
You may thaw frozen medicine either in a refrigerator or at room temperature. Do not heat the medicine under hot water or in a microwave.
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using Zosyn?
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.
Zosyn side effects
Get emergency medical help if you have signs of an allergic reaction to Zosyn: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
severe stomach pain, diarrhea that is watery or bloody;
a seizure (convulsions);
low white blood cell countsIclusigfever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing;
low potassiumIclusigleg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling;
signs of inflammation in your bodyIclusigswollen glands, flu symptoms, easy bruising or bleeding, severe tingling or numbness, muscle weakness, upper stomach pain, jaundice (yellowing of the skin or eyes), chest pain, new or worsening cough with fever, trouble breathing; or
severe skin reactionIclusigfever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common Zosyn side effects may include:
sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Zosyn?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Tell your doctor about all your current medicines and any you start or stop using, especially:
tobramycin, vancomycin or other injected antibiotics; or
medicine to prevent blood clots, such as dabigatran (Pradaxa), heparin, warfarin (Coumadin, Jantoven), and others.
This list is not complete. Other drugs may interact with piperacillin and tazobactam, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Zosyn only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 6.01.
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- Drug class: beta-lactamase inhibitors