Prilosec OTC Drug Interactions
Currently displaying a list of 242 drugs known to interact with Prilosec OTC (omeprazole).
- 25 major drug interactions
- 169 moderate drug interactions
- 48 minor drug interactions
Medications known to interact with Prilosec OTC
Note: Showing generic names only.
- abametapir topical
- abrocitinib
- acalabrutinib
- acetohexamide
- adagrasib
- alprazolam
- ambrisentan
- amikacin
- amikacin liposome
- amphetamine
- amphotericin b
- amphotericin b cholesteryl sulfate
- amphotericin b lipid complex
- amphotericin b liposomal
- anagrelide
- anisindione
- apalutamide
- armodafinil
- aspirin
- atazanavir
- atezolizumab
- atorvastatin
- avelumab
- axitinib
- bacampicillin
- belumosudil
- belzutifan
- bendamustine
- bendroflumethiazide
- benzthiazide
- binimetinib
- bismuth subcitrate potassium
- bortezomib
- bosutinib
- brivaracetam
- bumetanide
- cannabidiol
- capecitabine
- capmatinib
- capreomycin
- carbonyl iron
- carboplatin
- cefditoren
- cefpodoxime
- cefuroxime
- cemiplimab
- cenobamate
- ceritinib
- cetuximab
- chlordiazepoxide
- chlorothiazide
- chlorpropamide
- chlorthalidone
- choline salicylate
- cilostazol
- ciprofloxacin
- cisplatin
- citalopram
- clarithromycin
- clobazam
- clonazepam
- clopidogrel
- clorazepate
- clozapine
- cosibelimab
- cyanocobalamin
- cyclosporine
- dabigatran
- dacomitinib
- dasatinib
- delavirdine
- diazepam
- dicumarol
- digoxin
- dimethyl fumarate
- diroximel fumarate
- disulfiram
- dostarlimab
- duloxetine
- durvalumab
- duvelisib
- fedratinib
- fenfluramine
- fenofibrate
- ferric maltol
- ferrous fumarate
- ferrous gluconate
- ferrous sulfate
- fexinidazole
- flibanserin
- fluconazole
- flurazepam
- fluvoxamine
- fosamprenavir
- foscarnet
- fosphenytoin
- fostamatinib
- furosemide
- indapamide
- indinavir
- infigratinib
- ipilimumab
- iron bisglycinate
- iron polysaccharide
- iron protein succinylate
- isosorbide dinitrate
- isosorbide mononitrate
- itraconazole
- lapatinib
- larotrectinib
- lenacapavir
- letermovir
- levobupivacaine
- levoketoconazole
- levothyroxine
- levothyroxine / liothyronine
- lidocaine
- linaclotide
- liothyronine
- liotrix
- lonafarnib
- lovastatin
- magnesium salicylate
- mavacamten
- melatonin
- mephenytoin
- methadone
- methotrexate
- methyclothiazide
- methylcobalamin
- metolazone
- midazolam
- mitapivat
- modafinil
- monomethyl fumarate
- multivitamin with iron
- multivitamin with iron and fluoride
- multivitamin, prenatal
- mycophenolate mofetil
- naproxen
- nelfinavir
- neomycin
- neratinib
- netilmicin
- nifedipine
- nilotinib
- nirogacestat
- nisoldipine
- nitroglycerin
- nivolumab
- panitumumab
- paromomycin
- patiromer
- pazopanib
- pembrolizumab
- pemigatinib
- pentamidine
- peppermint oil
- pexidartinib
- phenobarbital
- phenytoin
- pirfenidone
- pirtobrutinib
- plazomicin
- polythiazide
- ponatinib
- posaconazole
- pralsetinib
- prasugrel
- salsalate
- saquinavir
- selpercatinib
- selumetinib
- simvastatin
- sodium polystyrene sulfonate
- sodium salicylate
- sonidegib
- sotorasib
- sparsentan
- st. john's wort
- stiripentol
- streptomycin
- tacrolimus
- tasimelteon
- theophylline
- thyroid desiccated
- tipranavir
- tislelizumab
- tobramycin
- tofacitinib
- tolazamide
- tolbutamide
- toripalimab
- torsemide
- trazodone
- tremelimumab
- treosulfan
- triazolam
- trichlormethiazide
- trofinetide
- trovafloxacin
Prilosec OTC disease interactions
There are 3 disease interactions with Prilosec OTC (omeprazole) which include:
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- During pregnancy
- Drug class: proton pump inhibitors
- Breastfeeding
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
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Ozempic
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Pepcid
Pepcid is used to treat ulcers in the stomach and for conditions where the stomach produces too ...
Prilosec
Prilosec (omeprazole) is used to treat symptoms of GERD and other conditions caused by excess ...
Pepto-Bismol
Pepto-Bismol is antacid used to treat heart burn, indigestion, diarrhea, gas or an upset stomach ...
Cimetidine
Cimetidine systemic is used for bronchogenic carcinoma, cutaneous mastocytosis, duodenal ulcer ...
Sodium bicarbonate
Sodium bicarbonate systemic is used for acidosis, alkylating agent cystitis, asystole, diabetic ...
Magnesium oxide
Magnesium oxide systemic is used for constipation, duodenal ulcer, GERD, hypomagnesemia ...
Calcium carbonate
Calcium carbonate systemic is used for duodenal ulcer, erosive esophagitis, GERD, hypocalcemia ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.