Prilosec OTC Drug Interactions
Currently displaying a list of 240 drugs known to interact with Prilosec OTC (omeprazole).
- 25 major drug interactions
- 167 moderate drug interactions
- 48 minor drug interactions
Medications known to interact with Prilosec OTC
Note: Showing generic names only.
A
- abametapir topical
- abrocitinib
- acalabrutinib
- acetohexamide
- adagrasib
- alprazolam
- ambrisentan
- amikacin
- amikacin liposome
- amphetamine
- amphotericin b
- amphotericin b cholesteryl sulfate
- amphotericin b lipid complex
- amphotericin b liposomal
- anagrelide
- anisindione
- apalutamide
- armodafinil
- aspirin
- atazanavir
- atezolizumab
- atorvastatin
- avelumab
- axitinib
B
- bacampicillin
- belumosudil
- belzutifan
- bendamustine
- bendroflumethiazide
- benzthiazide
- binimetinib
- bortezomib
- bosutinib
- brivaracetam
- bumetanide
C
- cannabidiol
- capecitabine
- capmatinib
- capreomycin
- carbonyl iron
- carboplatin
- cefditoren
- cefpodoxime
- cefuroxime
- cemiplimab
- cenobamate
- ceritinib
- cetuximab
- chlordiazepoxide
- chlorothiazide
- chlorpropamide
- chlorthalidone
- choline salicylate
- cilostazol
- ciprofloxacin
- cisplatin
- citalopram
- clarithromycin
- clobazam
- clonazepam
- clopidogrel
- clorazepate
- clozapine
- cosibelimab
- cyanocobalamin
- cyclosporine
D
- dabigatran
- dacomitinib
- dasatinib
- delavirdine
- diazepam
- dicumarol
- digoxin
- dimethyl fumarate
- diroximel fumarate
- disulfiram
- dostarlimab
- duloxetine
- durvalumab
- duvelisib
E
F
- fedratinib
- fenfluramine
- fenofibrate
- ferric maltol
- ferrous fumarate
- ferrous gluconate
- ferrous sulfate
- fexinidazole
- flibanserin
- fluconazole
- flurazepam
- fluvoxamine
- fosamprenavir
- foscarnet
- fosphenytoin
- fostamatinib
- furosemide
G
H
I
- indapamide
- indinavir
- infigratinib
- ipilimumab
- iron bisglycinate
- iron polysaccharide
- iron protein succinylate
- isosorbide dinitrate
- isosorbide mononitrate
- itraconazole
K
L
- lapatinib
- larotrectinib
- lenacapavir
- letermovir
- levobupivacaine
- levoketoconazole
- levothyroxine
- levothyroxine / liothyronine
- lidocaine
- linaclotide
- liothyronine
- liotrix
- lonafarnib
- lovastatin
M
- magnesium salicylate
- mavacamten
- melatonin
- mephenytoin
- methadone
- methotrexate
- methyclothiazide
- methylcobalamin
- metolazone
- midazolam
- mitapivat
- modafinil
- monomethyl fumarate
- multivitamin with iron
- multivitamin with iron and fluoride
- multivitamin, prenatal
- mycophenolate mofetil
N
- naproxen
- nelfinavir
- neomycin
- neratinib
- netilmicin
- nifedipine
- nilotinib
- nirogacestat
- nisoldipine
- nitroglycerin
- nivolumab
O
P
- panitumumab
- paromomycin
- patiromer
- pazopanib
- pembrolizumab
- pemigatinib
- pentamidine
- peppermint oil
- pexidartinib
- phenobarbital
- phenytoin
- pirfenidone
- pirtobrutinib
- plazomicin
- polythiazide
- ponatinib
- posaconazole
- pralsetinib
- prasugrel
Q
R
S
- salsalate
- saquinavir
- selpercatinib
- selumetinib
- simvastatin
- sodium polystyrene sulfonate
- sodium salicylate
- sonidegib
- sotorasib
- sparsentan
- st. john's wort
- stiripentol
- streptomycin
T
- tacrolimus
- tasimelteon
- theophylline
- thyroid desiccated
- tipranavir
- tislelizumab
- tobramycin
- tofacitinib
- tolazamide
- tolbutamide
- toripalimab
- torsemide
- trazodone
- tremelimumab
- treosulfan
- triazolam
- trichlormethiazide
- trofinetide
- trovafloxacin
V
W
Prilosec OTC disease interactions
There are 3 disease interactions with Prilosec OTC (omeprazole) which include:
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.