Provigil Drug Interactions
Currently displaying a list of 522 drugs known to interact with Provigil (modafinil).
- 77 major drug interactions
- 265 moderate drug interactions
- 180 minor drug interactions
Medications known to interact with Provigil
Note: Showing generic names only.
A
- abametapir topical
- abemaciclib
- abrocitinib
- acalabrutinib
- albendazole
- albuterol
- alfentanil
- alfuzosin
- almotriptan
- alprazolam
- ambrisentan
- aminoglutethimide
- aminophylline
- amiodarone
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amphetamine
- amprenavir
- anisindione
- apalutamide
- apixaban
- apraclonidine ophthalmic
- apremilast
- aprepitant
- arformoterol
- aripiprazole
- armodafinil
- asciminib
- astemizole
- atazanavir
- atogepant
- atomoxetine
- atorvastatin
- avacopan
- avanafil
- avapritinib
- axitinib
B
- bedaquiline
- belumosudil
- belzutifan
- benzphetamine
- bepridil
- berotralstat
- betamethasone
- betrixaban
- bexarotene
- binimetinib
- bitolterol
- boceprevir
- bortezomib
- bosentan
- bosutinib
- brexpiprazole
- brigatinib
- brivaracetam
- bromocriptine
- budesonide
- buprenorphine
- bupropion
- buspirone
- busulfan
- butabarbital
- butalbital
- butorphanol
C
- cabazitaxel
- cabozantinib
- caffeine
- capivasertib
- capmatinib
- carbamazepine
- cariprazine
- carisoprodol
- caspofungin
- cenobamate
- ceritinib
- cerivastatin
- cevimeline
- chloramphenicol
- chlordiazepoxide
- chlorotrianisene
- cilostazol
- cimetidine
- ciprofloxacin
- cisapride
- citalopram
- clarithromycin
- clobazam
- clomipramine
- clonazepam
- clopidogrel
- clorazepate
- clotrimazole
- clozapine
- cobicistat
- cobimetinib
- cocaine nasal
- cocaine topical
- codeine
- colchicine
- conivaptan
- conjugated estrogens
- copanlisib
- cortisone
- crinecerfont
- crizotinib
- cyclobenzaprine
- cyclophosphamide
- cyclosporine
D
- dabrafenib
- daclatasvir
- danazol
- dapsone
- dapsone topical
- daridorexant
- darifenacin
- darolutamide
- darunavir
- dasatinib
- deferasirox
- deflazacort
- dehydroepiandrosterone
- delavirdine
- desipramine
- dexamethasone
- dexmethylphenidate
- dextroamphetamine
- diazepam
- diclofenac
- dicumarol
- diethylpropion
- diethylstilbestrol
- dihydroergotamine
- diltiazem
- disopyramide
- dobutamine
- docetaxel
- dofetilide
- dolutegravir
- donepezil
- dopamine
- doravirine
- doxapram
- doxepin
- doxepin topical
- doxorubicin
- doxorubicin liposomal
- dronabinol
- dronedarone
- drospirenone
- dutasteride
- duvelisib
E
- echinacea
- efavirenz
- elacestrant
- elafibranor
- elagolix
- eletriptan
- eliglustat
- elvitegravir
- encorafenib
- enfortumab vedotin
- entrectinib
- enzalutamide
- ephedrine
- epinephrine
- eplerenone
- erdafitinib
- ergonovine
- ergotamine
- erlotinib
- erythromycin
- escitalopram
- esketamine
- eslicarbazepine
- esomeprazole
- estazolam
- esterified estrogens
- estradiol
- estrone
- estropipate
- eszopiclone
- ethinyl estradiol
- ethosuximide
- etonogestrel
- etoposide
- etravirine
- everolimus
- exemestane
F
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fentanyl
- fesoterodine
- fexinidazole
- finerenone
- flibanserin
- fluconazole
- fludrocortisone
- flurazepam
- fluvoxamine
- formoterol
- fosamprenavir
- fosaprepitant
- fosphenytoin
- fostamatinib
- fostemsavir
- fruquintinib
G
- ganaxolone
- gefitinib
- gepirone
- gilteritinib
- givinostat
- glasdegib
- glycerol phenylbutyrate
- goldenseal
- granisetron
- grepafloxacin
- griseofulvin
- guanfacine
H
- halazepam
- halofantrine
- haloperidol
- halothane
- hydrocodone
- hydrocortisone
- hydroxychloroquine
- hydroxyprogesterone
I
- ibrexafungerp
- ibrutinib
- idelalisib
- ifosfamide
- imatinib
- imipramine
- indacaterol
- indinavir
- infigratinib
- ioflupane I 123
- iptacopan
- irinotecan
- irinotecan liposomal
- isavuconazonium
- isoetharine
- isoniazid
- isoproterenol
- isradipine
- istradefylline
- itraconazole
- ivabradine
- ivacaftor
- ivermectin
- ivosidenib
- ixabepilone
- ixazomib
K
L
- lapatinib
- larotrectinib
- lazertinib
- lefamulin
- lemborexant
- lenacapavir
- leniolisib
- lesinurad
- letermovir
- letrozole
- levalbuterol
- levamlodipine
- levobupivacaine
- levoketoconazole
- levomethadyl acetate
- levonorgestrel
- lidocaine
- linagliptin
- lisdexamfetamine
- lomitapide
- lonafarnib
- lonapegsomatropin
- loratadine
- lorlatinib
- lovastatin
- lumateperone
- lurasidone
- lurbinectedin
M
- ma huang
- macimorelin
- macitentan
- maraviroc
- maribavir
- mavacamten
- mavorixafor
- mazindol
- medroxyprogesterone
- mefloquine
- megestrol
- melatonin
- mephentermine
- mephenytoin
- mephobarbital
- metaproterenol
- metaraminol
- methadone
- methamphetamine
- methoxamine
- methylergonovine
- methylphenidate
- methylprednisolone
- methysergide maleate
- metreleptin
- mibefradil
- miconazole
- midazolam
- midostaurin
- mifepristone
- mirabegron
- mirtazapine
- mitapivat
- mitotane
- mobocertinib
N
- nafcillin
- naldemedine
- naloxegol
- nefazodone
- nelfinavir
- neratinib
- nevirapine
- nicardipine
- nifedipine
- nilotinib
- nimodipine
- nirogacestat
- nisoldipine
- nitisinone
- norepinephrine
- norethindrone
- norgestrel
- nortriptyline
O
- olaparib
- oliceridine
- olodaterol
- olutasidenib
- omaveloxolone
- omeprazole
- ondansetron
- oritavancin
- osilodrostat
- osimertinib
- oxcarbazepine
- oxybutynin
- oxycodone
P
- paclitaxel
- paclitaxel protein-bound
- pacritinib
- palbociclib
- palovarotene
- panobinostat
- pantoprazole
- pazopanib
- pemigatinib
- pentobarbital
- perampanel
- pexidartinib
- phendimetrazine
- phenobarbital
- phentermine
- phenylbutazone
- phenylephrine
- phenylpropanolamine
- phenytoin
- pimavanserin
- pimozide
- pioglitazone
- pirbuterol
- pirtobrutinib
- pitolisant
- ponatinib
- posaconazole
- pralsetinib
- praziquantel
- prednisolone
- prednisone
- pretomanid
- primidone
- progesterone
- proguanil
- propranolol
- protriptyline
- pseudoephedrine
Q
R
- rabeprazole
- racepinephrine
- ramelteon
- ranolazine
- red yeast rice
- relugolix
- remdesivir
- repaglinide
- repotrectinib
- revumenib
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rilpivirine
- rimegepant
- riociguat
- ripretinib
- ritlecitinib
- ritodrine
- ritonavir
- rivaroxaban
- rolapitant
- rucaparib
- rufinamide
- ruxolitinib
- ruxolitinib topical
S
- salmeterol
- saquinavir
- saxagliptin
- secobarbital
- selpercatinib
- selumetinib
- sildenafil
- silodosin
- simvastatin
- siponimod
- sirolimus
- sirolimus protein-bound
- sodium phenylbutyrate
- sofosbuvir
- solifenacin
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sonidegib
- sorafenib
- sotorasib
- sparsentan
- st. john's wort
- stiripentol
- sufentanil
- sulfinpyrazone
- sunitinib
- suvorexant
- suzetrigine
T
- tacrolimus
- tadalafil
- taletrectinib
- tamoxifen
- tasimelteon
- tazemetostat
- tecovirimat
- telaprevir
- telithromycin
- telotristat
- temsirolimus
- teniposide
- tepotinib
- terbutaline
- terfenadine
- testosterone
- testosterone topical
- theophylline
- thiotepa
- tiagabine
- ticagrelor
- tirzepatide
- tofacitinib
- tolterodine
- tolvaptan
- toremifene
- tovorafenib
- trabectedin
- tramadol
- trazodone
- treosulfan
- tretinoin
- triamcinolone
- triazolam
- trimipramine
- trofinetide
- troglitazone
- troleandomycin
- tucatinib
U
V
- vadadustat
- valdecoxib
- vamorolone
- vardenafil
- vemurafenib
- venetoclax
- verapamil
- vilazodone
- viloxazine
- vinblastine
- vincristine
- vincristine liposome
- vinorelbine
- voclosporin
- vonoprazan
- vorasidenib
- voriconazole
- voxelotor
W
Z
Provigil alcohol/food interactions
There are 4 alcohol/food interactions with Provigil (modafinil).
Provigil disease interactions
There are 5 disease interactions with Provigil (modafinil) which include:
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
