Metformin Drug Interactions
Currently displaying a list of 377 drugs known to interact with metformin.
- 24 major drug interactions
- 344 moderate drug interactions
- 9 minor drug interactions
Medications known to interact with metformin
Note: Showing generic names only.
A
- abemaciclib
- acalabrutinib
- acarbose
- acetazolamide
- acetohexamide
- adefovir
- albuterol
- alclometasone topical
- aloe vera
- alpelisib
- alpha-lipoic acid
- amcinonide topical
- amiloride
- amprenavir
- anisindione
- arimoclomol
- aripiprazole
- asenapine
- ashwaganda
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atazanavir
B
- benazepril
- bendroflumethiazide
- benzphetamine
- benzthiazide
- betamethasone
- betamethasone topical
- bortezomib
- brentuximab
- brexpiprazole
- brigatinib
- bromfenac
- bumetanide
C
- calaspargase pegol
- capmatinib
- captopril
- cariprazine
- celecoxib
- cephalexin
- ceritinib
- chlorothiazide
- chlorotrianisene
- chlorpromazine
- chlorpropamide
- chlorthalidone
- chromic chloride hexahydrate
- chromium picolinate
- cimetidine
- cinnamon
- cinoxacin
- ciprofloxacin
- clarithromycin
- clobetasol topical
- clocortolone topical
- clozapine
- colesevelam
- conjugated estrogens
- conjugated estrogens topical
- copanlisib
- corticorelin
- corticotropin
- cortisone
- cosyntropin
- crizotinib
D
- dabrafenib
- daclatasvir
- dalfampridine
- danazol
- darunavir
- deflazacort
- delafloxacin
- desonide topical
- desoximetasone topical
- dexamethasone
- dexamethasone ophthalmic
- dexamethasone topical
- dexfenfluramine
- diatrizoate
- diazoxide
- dichlorphenamide
- diclofenac
- dicumarol
- dienestrol topical
- diethylpropion
- diethylstilbestrol
- diflorasone topical
- diflunisal
- digoxin
- dobutamine
- dofetilide
- dolutegravir
- dopamine
- drospirenone
E
- enalapril
- enalaprilat
- encorafenib
- enfortumab vedotin
- enoxacin
- entecavir
- ephedrine
- epinephrine
- erdafitinib
- esterified estrogens
- estradiol
- estradiol topical
- estramustine
- estrone
- estropipate
- estropipate topical
- ethacrynic acid
- ethanol
- ethinyl estradiol
- etodolac
- etonogestrel
- everolimus
F
- fedratinib
- fenfluramine
- fenoprofen
- fexinidazole
- fludrocortisone
- fluocinolone topical
- fluocinonide topical
- fluphenazine
- flurandrenolide topical
- flurbiprofen
- fluticasone topical
- formoterol
- fosamprenavir
- fosinopril
- fosphenytoin
- furosemide
G
- garlic
- gatifloxacin
- gemifloxacin
- gilteritinib
- ginseng
- givinostat
- glimepiride
- glipizide
- glucagon
- glyburide
- goserelin
- grepafloxacin
- guanfacine
- guar gum
H
- halcinonide topical
- halobetasol topical
- haloperidol
- heroin
- histrelin
- hydrochlorothiazide
- hydrocortisone
- hydrocortisone topical
- hydroflumethiazide
- hydroxyprogesterone
I
- ibuprofen
- iloperidone
- inavolisib
- indacaterol
- indapamide
- indinavir
- indomethacin
- insulin
- insulin aspart
- insulin aspart protamine
- insulin degludec
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation, rapid acting
- insulin isophane
- insulin lispro
- insulin lispro protamine
- insulin regular
- insulin zinc
- insulin zinc extended
- iodamide
- iodipamide
- iodixanol
- iohexol
- iomeprol
- iopamidol
- iopromide
- iothalamate
- ioversol
- ioxaglate
- ioxilan
- isavuconazonium
- isoniazid
- isoproterenol
- itraconazole
K
L
- lamotrigine
- lanreotide
- leuprolide
- levofloxacin
- levoketoconazole
- levonorgestrel
- levothyroxine
- levothyroxine / liothyronine
- liothyronine
- liotrix
- lisinopril
- lithium
- lomefloxacin
- lonapegsomatropin
- loncastuximab tesirine
- lorcaserin
- lumateperone
- lurasidone
M
- ma huang
- mavorixafor
- mazindol
- meclofenamate
- medroxyprogesterone
- mefenamic acid
- megestrol
- meloxicam
- memantine
- mephentermine
- mesoridazine
- metaproterenol
- metaraminol
- methadone
- methamphetamine
- methazolamide
- methdilazine
- methotrimeprazine
- methoxamine
- methyclothiazide
- methylprednisolone
- methylprednisolone topical
- metolazone
- metrizamide
- midodrine
- midostaurin
- moexipril
- mometasone topical
- morphine
- moxifloxacin
N
- nabumetone
- nalidixic acid
- naproxen
- nateglinide
- nelfinavir
- niacin
- niacinamide
- nicotinamide
- nifedipine
- niraparib
- norepinephrine
- norethindrone
- norfloxacin
- norgestrel
O
P
- pacritinib
- paliperidone
- pasireotide
- patiromer
- pegaspargase
- pegvisomant
- pemetrexed
- pentamidine
- perindopril
- perphenazine
- pexidartinib
- phendimetrazine
- phentermine
- phenylbutazone
- phenylephrine
- phenylpropanolamine
- phenytoin
- piroxicam
- pitolisant
- polythiazide
- porfimer
- pralsetinib
- prednicarbate topical
- prednisolone
- prednisone
- procainamide
- prochlorperazine
- progesterone
- progesterone topical
- promazine
- promethazine
- propiomazine
- pseudoephedrine
Q
R
- ramipril
- ranitidine
- ranitidine bismuth citrate
- ranolazine
- repaglinide
- ribociclib
- rifampin
- ripretinib
- risdiplam
- risperidone
- ritodrine
- ritonavir
- rofecoxib
- rucaparib
S
- salmeterol
- saquinavir
- selpercatinib
- sermorelin
- sibutramine
- simeprevir
- sirolimus
- sirolimus protein-bound
- sofosbuvir
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sparfloxacin
- spironolactone
- sucralfate
- sulindac
T
- tacrolimus
- tafenoquine
- tagraxofusp
- temsirolimus
- tenofovir alafenamide
- tenofovir disoproxil
- teprotumumab
- terbutaline
- tesamorelin
- thiethylperazine
- thioridazine
- thyroid desiccated
- thyrotropin alpha
- tipranavir
- tolazamide
- tolbutamide
- tolmetin
- topiramate
- torsemide
- trandolapril
- triamcinolone
- triamcinolone ophthalmic
- triamcinolone topical
- triamterene
- trichlormethiazide
- trifluoperazine
- triflupromazine
- trilaciclib
- trimeprazine
- trimethoprim
- triptorelin
- trospium
- trovafloxacin
- turmeric
V
W
Z
Metformin alcohol/food interactions
There is 1 alcohol/food interaction with metformin.
Metformin disease interactions
There are 5 disease interactions with metformin which include:
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- Drug class: non-sulfonylureas
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
