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Drug Interactions between hydrocortisone topical and metformin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs


hydrocortisone topical metFORMIN

Applies to: hydrocortisone topical and metformin

Some of the medication in hydrocortisone topical may be absorbed into the bloodstream following application to your skin. When present in sufficient concentrations in the blood, steroids like hydrocortisone topical can interfere with blood sugar control and reduce the effectiveness of metFORMIN and other diabetic medications. Although the absorption of most steroid preparations is limited when used as recommended in the product labeling, absorption may be increased under certain circumstances, such as: when the steroid is strong or highly potent; when the steroid is used for a longer duration; the person being treated is an infant or young child; or the area of skin being treated is large, inflamed, damaged (cut, scraped), thin (like the face), and/or covered with a dressing, wrapping or clothing. Blood sugar should be monitored closely in these situations. You may need a dose adjustment of metFORMIN and/or other diabetic medications if your blood sugar is affected. Talk to your health care provider if you have any questions or concerns. Do not exceed the recommended dose or frequency and duration of use when treated with products that contain steroids, including some over-the counter products. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions


metFORMIN food

Applies to: metformin

MetFORMIN should be taken with meals, and excessive alcohol intake (either short-term binge drinking or frequent consumption) should be avoided during treatment. Taking metFORMIN with alcohol may increase the risk of a rare but serious and potentially life-threatening condition known as lactic acidosis, which is a buildup of lactic acid in the blood that can occasionally occur during treatment with metformin-containing products. Lactic acidosis is more likely to occur if you have kidney or liver disease, acute or unstable congestive heart failure, or dehydration. You should seek immediate medical attention if you develop potential signs and symptoms of lactic acidosis such as fatigue, weakness, muscle pain, increasing drowsiness, abdominal pain or discomfort, slow or irregular heartbeat, breathing difficulty, chills, and other unusual symptoms. Alcohol may also affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink. You should avoid using alcohol if your diabetes is not well controlled or if you have high triglycerides, neuropathy (nerve damage), or pancreatitis. Moderate alcohol consumption generally does not affect blood glucose levels if your diabetes is under control. However, you should limit your alcohol intake due to the risk of lactic acidosis with metformin. Avoid drinking alcohol on an empty stomach or following exercise, as it may increase the risk of hypoglycemia. Talk to your doctor or pharmacist if you have any questions or concerns about metformin.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.