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Demerol (meperidine) Drug Interactions

A total of 825 drugs are known to interact with Demerol (meperidine).

  • 289 major drug interactions
  • 529 moderate drug interactions
  • 7 minor drug interactions

Show all medications in the database that may interact with Demerol (meperidine).

Check for interactions

Type in a drug name to check for interactions with Demerol (meperidine).

Most frequently checked interactions

View interaction reports for Demerol (meperidine) and the medicines listed below.

  • Aleve (naproxen)
  • Ambien (zolpidem)
  • aspirin (Aspir 81, Ecotrin, Acetylsalicylic Acid, Aspirin Low Strength, Bayer Aspirin, Aspir-Low, Arthritis Pain, Bufferin, Ascriptin, Easprin, Fasprin, Aspergum, Empirin, Aspiritab, Bayer Children's Aspirin, Durlaza, Ascriptin Enteric, Entercote, Acuprin 81, Aspirin Lite Coat, Aspi-Cor, Aspirtab, Halfprin, Ecotrin Adult Low Strength, Buffered Aspirin, St. Joseph Aspirin, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Bufferin Low Dose, Medi-Seltzer, Sloprin, St. Joseph 81 mg Chewable Aspirin, ZORprin, Low Dose ASA, Bayer Aspirin Extra Strength Plus, Buffex, Ecotrin Maximum Strength, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Bufferin Extra Strength, Therapy Bayer, Stanback Analgesic, Norwich Aspirin, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Ecpirin, Bayer Women's Aspirin With Calcium, Zero-Order Release, YSP Aspirin, Miniprin, Bayer Aspirin Regimen, Migralex, Heartline, Bayer Advanced Aspirin, Buffasal)
  • Ativan (lorazepam)
  • Benadryl (diphenhydramine)
  • Cymbalta (duloxetine)
  • Dilaudid (hydromorphone)
  • fentanyl (Fentanyl Transdermal System, Duragesic, Sublimaze, Fentora, Actiq, Abstral, Subsys, Lazanda, Onsolis, Ionsys)
  • Flexeril (cyclobenzaprine)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • hydrocodone (Hysingla ER, Zohydro ER, Vantrela ER)
  • ibuprofen (Advil, Motrin, IBU, Advil Liqui-Gels, Motrin IB, Proprinal, Advil Children's, Caldolor, Children's Motrin, Childrens Ibuprofen Berry, Motrin Childrens, Rufen, Ibuprofen PMR, Ibu-8, Motrin Pediatric, Menadol, Nuprin, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Advil Migraine, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, NeoProfen, Ibu-Tab, Genpril, Haltran, IBU-200, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Actiprofen, Addaprin, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, Motrin Junior Strength, Motrin Infant Drops, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • methadone (Dolophine, Methadose, Methadone Diskets, Methadose Sugar-Free)
  • morphine (MS Contin, Morphine Sulfate ER, Roxanol, Morphine Sulfate IR, Kadian, MorphaBond ER, Duramorph, MSIR, Statex, Arymo ER, Avinza, M-Eslon, Morphine Sulfate SR, Morphine LP Epidural, Oramorph SR, Astramorph PF, Infumorph, Morphine Rapi-Ject, RMS, Mitigo, Duramorph PF, OMS, Roxanol 100, Rescudose, MS/S, Roxanol-T, Doloral, Doloral Sirop, Morphitec, M O S)
  • naproxen (Aleve, Naprosyn, Naproxen Sodium DS, Anaprox, Naprelan, Anaprox-DS, EC-Naprosyn, Midol Extended Relief, Flanax Pain Reliever, Aflaxen, Comfort Pac with Naproxen, Leader Naproxen Sodium, Pamprin All Day Relief, All Day Pain Relief, All Day Relief)
  • oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, Dazidox, Oxyfast, Oxecta, Oxydose, RoxyBond, Percolone, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol)
  • Percocet (acetaminophen / oxycodone)
  • Phenergan (promethazine)
  • prednisone (Deltasone, Rayos, Sterapred, Prednicot, Meticorten, Sterapred DS, Liquid Pred, Orasone, Prednicen-M)
  • promethazine (Phenergan, Promethegan, Phenadoz, V-Gan-25, Anergan 50, Adgan, Phenazine 50, Phenergan Fortis, Antinaus 50, V-Gan-50, Phenoject-50, Pro-Med)
  • Suboxone (buprenorphine / naloxone)
  • Synthroid (levothyroxine)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Zydol, Tramahexal, Ryzolt, Tramal SR, ConZip, Larapam SR, GenRx Tramadol, Tramedo, Zamadol, Tramahexal SR, Zydol XL, Rybix ODT, Ultram ODT)
  • Tylenol (acetaminophen)
  • Versed (midazolam)
  • Vicodin (acetaminophen / hydrocodone)
  • Vistaril (hydroxyzine)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zofran (ondansetron)

Demerol (meperidine) alcohol/food interactions

There is 1 alcohol/food interaction with Demerol (meperidine)

Demerol (meperidine) disease interactions

There are 16 disease interactions with Demerol (meperidine) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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