Generic name: MEPERIDINE HYDROCHLORIDE 50mg
Dosage form: tablet
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2.1 Important Dosage and Administration Instructions
Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals [see Warnings and Precautions (5)].
Initiate the dosing regimen for each patient individually, taking into account the patient's severity of pain, patient response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse [see Warnings and Precautions (5.1)].
Monitor patients closely for respiratory depression, especially within the first 24-72 hours of initiating therapy and following dosage increases with DEMEROL Tablets and adjust the dosage accordingly [see Warnings and Precautions (5.2)].
2.2 Initial Dosage
Initiate treatment with DEMEROL Tablets in a dosing range of 50 mg to 150 mg orally, every 3 or 4 hours as needed for pain.
Initiate treatment with DEMEROL Tablets in a dosing range of 1.1 mg/kg to 1.8 mg/kg orally, up to the adult dose, every 3 or 4 hours as necessary.
2.3 Dosage Modification with Concomitant Use with Phenothiazines
The dose of DEMEROL should be reduced by 25 to 50% when administered concomitantly with phenothiazines and other tranquilizers.
2.4 Titration and Maintenance of Therapy
Individually titrate DEMEROL Tablets to a dose that provides adequate analgesia and minimizes adverse reactions. If adequate pain management cannot be achieved with a total daily dosage of 600 mg or less, discontinue treatment with DEMEROL by tapering the dose and select an alternate analgesic.
Continually reevaluate patients receiving DEMEROL to assess the maintenance of pain control and the relative incidence of adverse reactions, as well as monitoring for the development of addiction, abuse, or misuse [see Warnings and Precautions (5.1)]. Frequent communication is important among the prescriber, other members of the healthcare team, the patient, and the caregiver/family during periods of changing analgesic requirements, including initial titration.
If the level of pain increases after dosage stabilization, attempt to identify the source of increased pain before increasing the DEMEROL Tablets dosage. If unacceptable opioid-related adverse reactions are observed, consider reducing the dosage. Adjust the dosage to obtain an appropriate balance between management of pain and opioid-related adverse reactions.
2.5 Discontinuation of DEMEROL Tablets
When a patient who has been taking DEMEROL Tablets regularly and may be physically dependent no longer requires therapy with DEMEROL Tablets, taper the dose gradually, by 25% to 50% every 2 to 4 days, while monitoring carefully for signs and symptoms of withdrawal. If the patient develops these signs or symptoms, raise the dose to the previous level and taper more slowly, either by increasing the interval between decreases, decreasing the amount of change in dose, or both. Do not abruptly discontinue DEMEROL Tablets in a physically-dependent patient. [see Warnings and Precautions (5.14), Drug Abuse and Dependence (9)].
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- Drug class: narcotic analgesics
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Other brands: Meperitab