Caplyta Drug Interactions
Currently displaying a list of 605 drugs known to interact with Caplyta (lumateperone).
- 167 major drug interactions
- 436 moderate drug interactions
- 2 minor drug interactions
Medications known to interact with Caplyta
Note: Showing generic names only.
A
- abametapir topical
- acarbose
- acebutolol
- acetohexamide
- acetylcarbromal
- acetylcholine ophthalmic
- acrivastine
- albiglutide
- alfentanil
- alfuzosin
- allopurinol
- alogliptin
- alprazolam
- amantadine
- amifampridine
- amiloride
- aminoglutethimide
- amiodarone
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amprenavir
- amyl nitrite
- apalutamide
- apomorphine
- apraclonidine ophthalmic
- aprepitant
- aprocitentan
- aripiprazole
- armodafinil
- asciminib
- asenapine
- atazanavir
- atenolol
- atropine
- avacopan
- azatadine
- azelastine nasal
- azilsartan medoxomil
B
- baclofen
- belladonna
- belzutifan
- benazepril
- bendroflumethiazide
- benzgalantamine
- benzthiazide
- benztropine
- bepridil
- berotralstat
- betaxolol
- bexagliflozin
- bexarotene
- bicalutamide
- biperiden
- bisoprolol
- boceprevir
- bosentan
- brexanolone
- brexpiprazole
- brigatinib
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- bumetanide
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
C
- cabergoline
- canagliflozin
- candesartan
- cannabidiol
- cannabis
- capivasertib
- captopril
- carbachol ophthalmic
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carteolol
- carvedilol
- cenobamate
- ceritinib
- cetirizine
- chlophedianol
- chloral hydrate
- chloramphenicol
- chloramphenicol ophthalmic
- chloramphenicol otic
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chlorothiazide
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorpropamide
- chlorthalidone
- chlorzoxazone
- cimetidine
- ciprofloxacin
- citalopram
- clarithromycin
- clemastine
- clevidipine
- clidinium
- clobazam
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clotrimazole
- clozapine
- cobicistat
- codeine
- conivaptan
- crizotinib
- cyclandelate
- cyclizine
- cyclobenzaprine
- cyclosporine
- cyproheptadine
D
- dabrafenib
- dacomitinib
- danazol
- dantrolene
- dapagliflozin
- daridorexant
- darifenacin
- darunavir
- dasatinib
- deferasirox
- delavirdine
- demecarium bromide ophthalmic
- deserpidine
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexamethasone
- dexbrompheniramine
- dexchlorpheniramine
- dexmedetomidine
- dextromethorphan
- dezocine
- diazepam
- diazoxide
- dicyclomine
- difelikefalin
- diltiazem
- dimenhydrinate
- diphenhydramine
- disopyramide
- divalproex sodium
- donepezil
- dopamine
- doxazosin
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- dronedarone
- droperidol
- dulaglutide
- duloxetine
- duvelisib
E
- echinacea
- echothiophate iodide ophthalmic
- efavirenz
- elafibranor
- elagolix
- eltrombopag
- empagliflozin
- enalapril
- enalaprilat
- encorafenib
- entacapone
- entrectinib
- enzalutamide
- epinephrine
- eplerenone
- eprosartan
- ertugliflozin
- erythromycin
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- estazolam
- eszopiclone
- ethacrynic acid
- ethanol
- ethaverine
- ethchlorvynol
- ethosuximide
- ethotoin
- etravirine
- evening primrose
- exenatide
- ezogabine
F
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fenoldopam
- fentanyl
- fesoterodine
- fexinidazole
- flavoxate
- flibanserin
- fluconazole
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- fosamprenavir
- fosaprepitant
- fosinopril
- fosphenytoin
- fostamatinib
- furosemide
G
- gabapentin
- gabapentin enacarbil
- galantamine
- ganaxolone
- gemfibrozil
- ginger
- ginkgo
- givinostat
- glimepiride
- glipizide
- glyburide
- glycerol phenylbutyrate
- glycopyrrolate
- goldenseal
- grepafloxacin
- griseofulvin
- guanabenz
- guanadrel
- guanethidine
- guanfacine
H
- halazepam
- haloperidol
- heroin
- hydralazine
- hydrochlorothiazide
- hydrocodone
- hydroflumethiazide
- hydromorphone
- hydroxyzine
- hyoscyamine
I
- idelalisib
- ifosfamide
- iloperidone
- imatinib
- imipramine
- indapamide
- indinavir
- insulin
- insulin aspart
- insulin aspart protamine
- insulin degludec
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation, rapid acting
- insulin isophane
- insulin lispro
- insulin lispro protamine
- insulin regular
- insulin zinc
- insulin zinc extended
- ioflupane I 123
- iohexol
- iomeprol
- iopamidol
- iptacopan
- irbesartan
- isavuconazonium
- isocarboxazid
- isoflurophate ophthalmic
- isoniazid
- isosorbide
- isosorbide dinitrate
- isosorbide mononitrate
- isoxsuprine
- isradipine
- itraconazole
- ivacaftor
- ivosidenib
K
L
- labetalol
- lamotrigine
- landiolol
- lanreotide
- lapatinib
- larotrectinib
- lasmiditan
- lazertinib
- lefamulin
- lemborexant
- lenacapavir
- lenvatinib
- lesinurad
- letermovir
- levamlodipine
- levetiracetam
- levocetirizine
- levodopa
- levoketoconazole
- levomethadyl acetate
- levomilnacipran
- levorphanol
- lidocaine
- linagliptin
- lindane topical
- liraglutide
- lisinopril
- lithium
- lixisenatide
- lofexidine
- lomitapide
- lonafarnib
- lonapegsomatropin
- lorazepam
- lorlatinib
- losartan
- loxapine
- lurasidone
M
- maprotiline
- mavacamten
- mavorixafor
- mecamylamine
- meclizine
- melatonin
- mepenzolate
- meperidine
- mephenytoin
- mephobarbital
- meprobamate
- mesoridazine
- metaxalone
- metformin
- methadone
- methdilazine
- methocarbamol
- methohexital
- methotrimeprazine
- methscopolamine
- methsuximide
- methyclothiazide
- methyldopa
- metoclopramide
- metolazone
- metoprolol
- metreleptin
- metrizamide
- metyrosine
- mibefradil
- midazolam
- mifepristone
- miglitol
- milnacipran
- minoxidil
- mirtazapine
- mitapivat
- mitotane
- mobocertinib
- modafinil
- moexipril
- molindone
- morphine
- morphine liposomal
N
- nabilone
- nadolol
- nafcillin
- nalbuphine
- nateglinide
- nebivolol
- nefazodone
- nelfinavir
- nevirapine
- nicardipine
- nifedipine
- nilotinib
- nimodipine
- nirogacestat
- nisoldipine
- nitroglycerin
- nitroprusside
- nortriptyline
O
- octreotide
- olanzapine
- oliceridine
- olmesartan
- olopatadine nasal
- olutasidenib
- omaveloxolone
- opicapone
- opium
- oritavancin
- orphenadrine
- osilodrostat
- oxazepam
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymorphone
P
- pacritinib
- palbociclib
- paliperidone
- papaverine
- paraldehyde
- paramethadione
- paroxetine
- pasireotide
- pazopanib
- penbutolol
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perindopril
- perphenazine
- pexidartinib
- phenacemide
- phenelzine
- phenindamine
- phenobarbital
- phenoxybenzamine
- phensuximide
- phentolamine
- phenytoin
- physostigmine
- physostigmine ophthalmic
- pilocarpine ophthalmic
- pimozide
- pindolol
- pioglitazone
- pirtobrutinib
- pitolisant
- polyethylene glycol 3350 with electrolytes
- polythiazide
- posaconazole
- pralsetinib
- pramipexole
- pramlintide
- prazosin
- prednisone
- pregabalin
- primidone
- probenecid
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propantheline
- propiomazine
- propoxyphene
- propranolol
- protriptyline
- pyrilamine
Q
R
- ramelteon
- ramipril
- ranolazine
- rasagiline
- rauwolfia serpentina
- regorafenib
- remdesivir
- remifentanil
- remimazolam
- repaglinide
- repotrectinib
- reserpine
- ribociclib
- rifabutin
- rifampin
- rifapentine
- risperidone
- ritlecitinib
- ritonavir
- rivastigmine
- ropinirole
- rosiglitazone
- rotigotine
- rucaparib
- rufinamide
S
- safinamide
- saquinavir
- saxagliptin
- scopolamine
- secobarbital
- selegiline
- selpercatinib
- semaglutide
- sertraline
- sibutramine
- silodosin
- sirolimus
- sitagliptin
- sodium oxybate
- solifenacin
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sorafenib
- sotagliflozin
- sotalol
- sotorasib
- sparsentan
- spironolactone
- st. john's wort
- stiripentol
- sufentanil
- suvorexant
- suzetrigine
T
- tacrine
- tacrolimus
- tamsulosin
- tapentadol
- tasimelteon
- tazemetostat
- tecovirimat
- telaprevir
- telithromycin
- telmisartan
- telotristat
- temazepam
- temsirolimus
- terazosin
- tetrabenazine
- thalidomide
- thiethylperazine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- ticagrelor
- timolol
- tirzepatide
- tizanidine
- tolazamide
- tolazoline
- tolbutamide
- tolcapone
- tolterodine
- topiramate
- torsemide
- tovorafenib
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- treosulfan
- triamterene
- triazolam
- trichlormethiazide
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethaphan camsylate
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- trofinetide
- troglitazone
- troleandomycin
- trospium
- tucatinib
V
- vadadustat
- valbenazine
- valerian
- valproic acid
- valsartan
- vemurafenib
- venlafaxine
- verapamil
- vigabatrin
- viloxazine
- vonoprazan
- vorasidenib
- voriconazole
- voxelotor
Z
Caplyta alcohol/food interactions
There are 4 alcohol/food interactions with Caplyta (lumateperone).
Caplyta disease interactions
There are 10 disease interactions with Caplyta (lumateperone) which include:
- suicidality
- dementia
- aspiration
- seizure
- hematologic abnormalities
- hyperglycemia/diabetes
- hypotension
- lipid alterations
- hepatic impairment
- tardive dyskinesia
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- Drug class: atypical antipsychotics
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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