Climara (estradiol) Drug Interactions
A total of 391 drugs are known to interact with Climara (estradiol).
- 9 major drug interactions
- 349 moderate drug interactions
- 33 minor drug interactions
Check for interactions
Most frequently checked interactions
View interaction reports for Climara (estradiol) and the medicines listed below.
- Allegra (fexofenadine)
- clonazepam (Klonopin, Klonopin Wafer)
- Cymbalta (duloxetine)
- Flonase (fluticasone nasal)
- gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
- grapefruit
- levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Levothyrox, Eltroxin, Euthyrox, Unithroid, Oroxine, Eutroxsig, Levo-T, L Thyroxine Roche, Novothyrox, Levotabs, Tirosint-Sol, Levotec, Evotrox)
- Lipitor (atorvastatin)
- Lyrica (pregabalin)
- Nexium (esomeprazole)
- omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
- oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, Oxyfast, Oxecta, RoxyBond, Percolone, Dazidox, Oxydose, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol)
- prednisone (Deltasone, Rayos, Sterapred, Prednicot, Meticorten, Sterapred DS, Liquid Pred, Orasone, Prednicen-M)
- progesterone (Prometrium, Crinone, Endometrin, Progest, Cyclogest, Menopause Formula Progesterone, First Progesterone MC10, First Progesterone MC5, Gestone, Prochieve)
- Provera (medroxyprogesterone)
- Synthroid (levothyroxine)
- trazodone (Desyrel, Oleptro, Desyrel Dividose)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zyrtec (cetirizine)
Climara (estradiol) alcohol/food interactions
There are 3 alcohol/food interactions with Climara (estradiol)
Climara (estradiol) disease interactions
There are 17 disease interactions with Climara (estradiol) which include:
- abnormal vaginal bleeding
- carcinomas (estrogenic)
- hypercalcemia in breast cancer
- hypertension
- thromboembolism/cardiovascular
- hepatic neoplasms
- angioedema
- gallbladder disease
- hypercalcemia
- hyperlipidemia
- liver disease
- melasma
- depression
- fluid retention
- glucose intolerance
- retinal thrombosis
- thyroid function tests
More about Climara (estradiol)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Support Group
- En Español
- 36 Reviews
- Generic Availability
- Drug class: estrogens
- FDA Alerts (3)
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
