Climara Interactions
There are 391 drugs known to interact with Climara (estradiol), along with 17 disease interactions, and 4 alcohol/food interactions. Of the total drug interactions, 35 are major, 336 are moderate, and 20 are minor.
- View all 391 medications that may interact with Climara
- View Climara alcohol/food interactions (4)
- View Climara disease interactions (17)
Most frequently checked interactions
View interaction reports for Climara (estradiol) and the medicines listed below.
- albuterol
- Allegra (fexofenadine)
- aspirin
- atorvastatin
- biotin
- bupropion
- Cymbalta (duloxetine)
- doxycycline
- Flonase (fluticasone nasal)
- gabapentin
- hydrochlorothiazide
- levothyroxine
- Lipitor (atorvastatin)
- Lyrica (pregabalin)
- metformin
- Nexium (esomeprazole)
- omeprazole
- oxycodone
- pantoprazole
- prednisone
- progesterone
- Prometrium (progesterone)
- Synthroid (levothyroxine)
- tramadol
- trazodone
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zyrtec (cetirizine)
Climara alcohol/food interactions
There are 4 alcohol/food interactions with Climara (estradiol).
Climara disease interactions
There are 17 disease interactions with Climara (estradiol) which include:
- abnormal vaginal bleeding
- carcinomas (estrogenic)
- hypercalcemia in breast cancer
- hypertension
- thromboembolism/cardiovascular
- hepatic neoplasms
- angioedema
- gallbladder disease
- hypercalcemia
- hyperlipidemia
- liver disease
- melasma
- depression
- fluid retention
- glucose intolerance
- retinal thrombosis
- thyroid function tests
Report options
More about Climara (estradiol)
- Climara consumer information
- Compare alternatives
- Reviews (62)
- Side effects
- Dosage information
- During pregnancy
- Generic availability
- Drug class: estrogens
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Estrace Vaginal Cream
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Vagifem
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Prempro
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Conjugated estrogens
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.