Sominex Interactions
There are 448 drugs known to interact with Sominex (diphenhydramine), along with 8 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 14 are major, 432 are moderate, and 2 are minor.
- View all 448 medications that may interact with Sominex
- View Sominex alcohol/food interactions (1)
- View Sominex disease interactions (8)
Most frequently checked interactions
View interaction reports for Sominex (diphenhydramine) and the medicines listed below.
- Ambien (zolpidem)
- amitriptyline
- amlodipine
- amoxicillin
- aspirin
- atorvastatin
- citalopram
- diazepam
- doxycycline
- Eliquis (apixaban)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flonase (fluticasone nasal)
- furosemide
- gabapentin
- hydralazine
- ibuprofen
- lansoprazole
- Lasix (furosemide)
- levothyroxine
- Lexapro (escitalopram)
- lisinopril
- melatonin
- metformin
- metoprolol
- potassium chloride
- sertraline
- tramadol
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
Sominex alcohol/food interactions
There is 1 alcohol/food interaction with Sominex (diphenhydramine).
Sominex disease interactions
There are 8 disease interactions with Sominex (diphenhydramine) which include:
- depression
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
More about Sominex (diphenhydramine)
- Sominex consumer information
- Compare alternatives
- Reviews (64)
- Drug images
- Latest FDA alerts (2)
- Side effects
- Dosage information
- During pregnancy
- Drug class: anticholinergic antiemetics
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.