Simply Sleep Interactions
There are 449 drugs known to interact with Simply Sleep (diphenhydramine), along with 8 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 15 are major, 431 are moderate, and 3 are minor.
- View all 449 medications that may interact with Simply Sleep
- View Simply Sleep alcohol/food interactions (1)
- View Simply Sleep disease interactions (8)
Most frequently checked interactions
View interaction reports for Simply Sleep (diphenhydramine) and the medicines listed below.
- Aleve (naproxen)
- amlodipine
- aspirin
- biotin
- Claritin (loratadine)
- clonazepam
- Flonase (fluticasone nasal)
- folic acid
- gabapentin
- hydrochlorothiazide
- hydroxyzine
- ibuprofen
- Lexapro (escitalopram)
- lisinopril
- melatonin
- meloxicam
- metformin
- Metoprolol Succinate ER (metoprolol)
- multivitamin
- omeprazole
- prednisone
- rosuvastatin
- trazodone
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zantac (ranitidine)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Simply Sleep alcohol/food interactions
There is 1 alcohol/food interaction with Simply Sleep (diphenhydramine).
Simply Sleep disease interactions
There are 8 disease interactions with Simply Sleep (diphenhydramine) which include:
- depression
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
Report options
More about Simply Sleep (diphenhydramine)
- Simply Sleep consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (20)
- Drug images
- Latest FDA alerts (3)
- Side effects
- Dosage information
- During pregnancy
- Drug class: anticholinergic antiemetics
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
