Acetaminophen/codeine Interactions
There are 611 drugs known to interact with acetaminophen/codeine, along with 19 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 133 are major, 465 are moderate, and 13 are minor.
- View all 611 medications that may interact with acetaminophen/codeine
- View acetaminophen/codeine alcohol/food interactions (2)
- View acetaminophen/codeine disease interactions (19)
Most frequently checked interactions
View interaction reports for acetaminophen / codeine and the medicines listed below.
- Aspirin Low Strength (aspirin)
- Benadryl (diphenhydramine)
- Claritin (loratadine)
- CoQ10 (ubiquinone)
- Cymbalta (duloxetine)
- Eliquis (apixaban)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flexeril (cyclobenzaprine)
- Flonase (fluticasone nasal)
- Lexapro (escitalopram)
- Lyrica (pregabalin)
- Metoprolol Succinate ER (metoprolol)
- Metoprolol Tartrate (metoprolol)
- MiraLAX (polyethylene glycol 3350)
- Nexium (esomeprazole)
- Norco (acetaminophen / hydrocodone)
- Ozempic (semaglutide)
- ProAir HFA (albuterol)
- Singulair (montelukast)
- Synthroid (levothyroxine)
- Tylenol (acetaminophen)
- Valium (diazepam)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D2 (ergocalciferol)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zofran (ondansetron)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Acetaminophen/codeine alcohol/food interactions
There are 2 alcohol/food interactions with acetaminophen / codeine.
Acetaminophen/codeine disease interactions
There are 19 disease interactions with acetaminophen / codeine which include:
- alcoholism
- liver disease
- impaired GI motility
- infectious diarrhea
- prematurity
- acute alcohol intoxication
- drug dependence
- hypotension
- intracranial pressure
- respiratory depression
- gastrointestinal obstruction
- PKU
- adrenal insufficiency
- liver disease
- renal dysfunction
- seizure disorders
- urinary retention
- arrhythmias
- biliary tract disease
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More about acetaminophen / codeine
- acetaminophen/codeine consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (231)
- Drug images
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Drug class: narcotic analgesic combinations
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
