Acetaminophen/codeine Interactions
There are 610 drugs known to interact with acetaminophen/codeine, along with 19 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 132 are major, 465 are moderate, and 13 are minor.
- View all 610 medications that may interact with acetaminophen/codeine
- View acetaminophen/codeine alcohol/food interactions (2)
- View acetaminophen/codeine disease interactions (19)
Most frequently checked interactions
View interaction reports for acetaminophen / codeine and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Aspirin Low Strength (aspirin)
- Benadryl (diphenhydramine)
- Claritin (loratadine)
- CoQ10 (ubiquinone)
- Cymbalta (duloxetine)
- Eliquis (apixaban)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flexeril (cyclobenzaprine)
- Flonase (fluticasone nasal)
- Lexapro (escitalopram)
- Lyrica (pregabalin)
- Metoprolol Succinate ER (metoprolol)
- Metoprolol Tartrate (metoprolol)
- MiraLAX (polyethylene glycol 3350)
- Nexium (esomeprazole)
- Norco (acetaminophen / hydrocodone)
- Ozempic (semaglutide)
- ProAir HFA (albuterol)
- Singulair (montelukast)
- Synthroid (levothyroxine)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D2 (ergocalciferol)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zofran (ondansetron)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Acetaminophen/codeine alcohol/food interactions
There are 2 alcohol/food interactions with acetaminophen / codeine.
Acetaminophen/codeine disease interactions
There are 19 disease interactions with acetaminophen / codeine which include:
- alcoholism
- liver disease
- impaired GI motility
- infectious diarrhea
- prematurity
- acute alcohol intoxication
- drug dependence
- hypotension
- intracranial pressure
- respiratory depression
- gastrointestinal obstruction
- PKU
- adrenal insufficiency
- liver disease
- renal dysfunction
- seizure disorders
- urinary retention
- arrhythmias
- biliary tract disease
Report options
More about acetaminophen / codeine
- acetaminophen/codeine consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (231)
- Drug images
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Drug class: narcotic analgesic combinations
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
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Naproxen
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Botox
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Hydroxyzine
Hydroxyzine is an antihistamine used to treat itching, hives, and anxiety. It also acts as a ...
Tramadol
Tramadol is an opioid medication that may be used to treat moderate to moderately severe chronic ...
Cyclobenzaprine
Cyclobenzaprine is a muscle relaxant and works by blocking pain sensations. Includes ...
Duloxetine
Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor antidepressant used to ...
Meloxicam
Meloxicam is a nonsteroidal anti-inflammatory drug used to treat pain or inflammation caused by ...
Aspirin
Aspirin is used to treat mild to moderate pain and to reduce fever or inflammation. Learn about ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
