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Acetaminophen/codeine: 7 things you should know

Medically reviewed by Carmen Pope, BPharm. Last updated on Nov 15, 2024.

1. How it works

2. Upsides

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

Acetaminophen/codeine may be used to treat mild-to-moderate pain that is unrelieved by nonopioid analgesics. However, the codeine component of this combination medicine is addictive and may cause constipation, and there is a wide variation in the way different individuals metabolize it, which can lead to either ineffectiveness or excessive side effects.

5. Tips

6. Response and effectiveness

7. Interactions

Medicines that interact with acetaminophen/codeine may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with acetaminophen/codeine. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Common medications that may interact with acetaminophen/codeine include:

Avoid drinking alcohol or taking illegal or recreational drugs while taking acetaminophen/codeine.

Note that this list is not all-inclusive and includes only common medications that may interact with acetaminophen/codeine. You should refer to the prescribing information for acetaminophen/codeine for a complete list of interactions.

References

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use acetaminophen/codeine only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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