Applies to the following strengths: 10 mg; 20 mg; 10 mg/10 mL
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Anesthesia
Initial dose: 0.08 to 0.1 mg/kg. Maintenance dose during prolonged surgical procedures: 0.01 to 0.015 mg/kg 25 to 40 minutes later, then as frequently as every 12 to 15 minutes.
Continuous infusion: Initiate with an intubating dose of 80 to 100 mcg/kg followed 20 to 40 minutes later with 0.8 to 1.2 mcg/kg/minute.
Renal Dose Adjustments
Vecuronium is well tolerated without clinically significant prolongation of neuromuscular blocking effect in patients with renal failure who have been optimally prepared for surgery by dialysis.
Liver Dose Adjustments
Vecuronium is not recommended for use in patients with hepatic disease/failure.
US BOXED WARNINGS:
-This drug should be administered by or under the supervision of experienced clinicians who are familiar with its actions and the possible complications that might occur and in facilities equipped with intubation, artificial respiration, oxygen therapy, and reversal agents.
-The clinician must be prepared to assist or control respiration to reduce the possibility of prolonged neuromuscular blockade and other possible complications that might occur following long-term use in the ICU.
Safety and effectiveness have not been established in pediatric patients less than 7 weeks of age.
Consult WARNINGS section for additional precautions.
Vecuronium is well tolerated without clinically significant prolongation of neuromuscular blocking effect in patients with renal failure who have been optimally prepared for surgery by dialysis. Under emergency conditions in anephric patients some prolongation of neuromuscular blockade may occur; therefore, if anephric patients cannot be prepared for non-elective surgery, a lower initial dose of vecuronium should be considered.
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- Drug class: neuromuscular blocking agents