Tuxarin Dosage

Important Dosage and Administration Instructions

Administer TUXARIN ER by the oral route only.

Advise patients not to increase the dose or dosing frequency of TUXARIN ER because serious adverse events such as respiratory depression may occur with overdosage. The dosage of TUXARIN ER should not be increased if cough fails to respond; an unresponsive cough should be reevaluated for possible underlying pathology.

Recommended Dosage

Monitoring, Maintenance, and Discontinuation of Therapy

Prescribe TUXARIN ER for the shortest duration that is consistent with individual patient treatment goals

Monitor patients closely for respiratory depression, especially within the first 24-72 hours of initiating therapy.

Reevaluate patients with unresponsive cough in 5 days or sooner for possible underlying pathology, such as foreign body or lower respiratory tract disease. If a patient requires a refill, reevaluate the cause of the cough and assess the need for continued treatment with TUXARIN ER, the relative incidence of adverse reactions, and the development of addiction, abuse, or misuse.

Do not abruptly discontinue TUXARIN ER in a physically-dependent patient. When a patient who has been taking TUXARIN ER regularly and may be physically dependent no longer requires therapy with TUXARIN ER, taper the dose gradually, by 25% to 50% every 2 to 4 days, while monitoring carefully for signs and symptoms of withdrawal. If the patient develops these signs or symptoms, raise the dose to the previous level and taper more slowly, either by increasing the interval between decreases, decreasing the amount of change in dose, or both.