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Tekturna Dosage

Generic name: ALISKIREN HEMIFUMARATE 150mg
Dosage form: tablet, film coated

Medically reviewed on November 21, 2017.

Adult Hypertension

The usual recommended starting dose of Tekturna is 150 mg once daily. In patients whose blood pressure is not adequately controlled, the daily dose may be increased to 300 mg. Doses above 300 mg did not give an increased blood pressure response but resulted in an increased rate of diarrhea. The antihypertensive effect of a given dose is substantially attained (85% to 90%) by 2 weeks.

Pediatric Hypertension 6 to 17 Years of Age

Tekturna is contraindicated in children less than 2 years of age [see Contraindications (4)].Tekturna should not be used in children aged 2 to less than 6 years of age or in children who weigh less than 20 kg [see Use in Specific Populations (8.4) and Nonclinical Toxicology (13.2)]. See Table 1 for recommended dosage in pediatric patients 6 to 17 years of age.

Table 1: Recommended dosage in pediatric patients 6 to 17 years of age
Weight Recommended dosage
Less than 20 kg Tekturna is not recommended
20 kg to 50 kg The recommended starting dose is 75 mg once daily. The
maximum recommended dose is 150 mg
Greater than or equal to 50 kg The recommended dose is the same as in adults.

Administration of Tekturna Oral Pellets

For patients unable to swallow tablets, Tekturna oral pellets can be used.

Tekturna Oral Pellets are provided in a dispensing capsule. Do not swallow the capsules containing Tekturna Oral Pellets. Do not empty the contents of the capsule directly into the mouth. Do not chew or crush the contents of the capsule.

Tekturna Oral Pellets may be taken by opening the dispensing capsule, emptying the contents into a spoon and then administering by mouth, follow with milk (dairy or soy-based) or water immediately without chewing or crushing. Make sure that no pellets remain in the dispensing capsule.

Alternatively, Tekturna Oral Pellets may be taken by carefully open the dispensing capsule and take the contents orally immediately after mixing with 1 or more teaspoons of vanilla pudding (milk or soy-based), vanilla ice cream (milk or soy- based), milk (dairy or soy-based), or water as a dosing vehicle. Dosing vehicles are limited to those specified. It is recommended that the contents of one dispensing capsule be taken with one teaspoon of dosing vehicle; however, more or less dosing vehicle may be administered, if desired. Do not chew or crush the contents of the capsules.

Relationship to Meals

Patients should establish a routine pattern for taking Tekturna with regard to meals. High-fat meals decrease absorption substantially [see Clinical Pharmacology (12.3)].

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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