Suvorexant Dosage

Medically reviewed by Drugs.com. Last updated on Mar 20, 2023.

Usual Adult Dose for Insomnia

10 mg orally once a day at bedtime
Maximum dose: 20 mg once a day

Comments:

• Take within 30 minutes of going to bed, with at least 7 hours remaining before the planned time of awakening.
• If 10 mg is well-tolerated but not effective, the dose can be increased.
• Time to effect may be delayed if taken with or soon after a meal.

Use: Insomnia characterized by difficulties with sleep onset and/or sleep maintenance.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Mild to moderate liver dysfunction (Child-Pugh up to 9): No adjustment recommended
Severe liver dysfunction: Not recommended

Dose Adjustments

This drug should be used at the lowest effective dose in order to achieve therapeutic efficacy and minimize adverse effects.

Special Populations:

• Exposure is increased in women and in obese patients. Particularly in obese women, the increased risk of adverse effects should be considered before increasing the dose.

CNS Depressants:

• When combined with other CNS depressant drugs, dosage adjustment of suvorexant and/or the other drug(s) may be necessary.

CYP450 3A4 inhibitors:

• If combined with a moderate inhibitor: 5 mg a day; generally not to exceed 10 mg a day
• If combined with a strong inhibitor: Not recommended

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule IV

Dialysis

Data not available

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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