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suvorexant (Oral route)


Commonly used brand name(s)

In the U.S.

  • Belsomra

Available Dosage Forms:

  • Tablet

Uses For suvorexant

Suvorexant is used to treat insomnia (trouble sleeping). It belongs to the group of medicines called central nervous system (CNS) depressants. These medicines will slow down the nervous system. Suvorexant will help you get to sleep faster and sleep through the night. In most cases, sleep medicines should only be used for short periods of time, such as 1 or 2 days, and for no longer than 1 or 2 weeks.

suvorexant is available only with your doctor's prescription.

Before Using suvorexant

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For suvorexant, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to suvorexant or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of suvorexant in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of suvorexant in the elderly.


Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking suvorexant, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using suvorexant with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Atazanavir
  • Boceprevir
  • Cobicistat
  • Delavirdine
  • Itraconazole
  • Ketoconazole
  • Lopinavir
  • Nelfinavir
  • Posaconazole
  • Ritonavir
  • Saquinavir
  • Telaprevir
  • Tipranavir

Using suvorexant with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acepromazine
  • Alfentanil
  • Alprazolam
  • Amisulpride
  • Anileridine
  • Aprepitant
  • Aripiprazole
  • Asenapine
  • Baclofen
  • Benperidol
  • Bromazepam
  • Buprenorphine
  • Buspirone
  • Butorphanol
  • Carbinoxamine
  • Carisoprodol
  • Carphenazine
  • Chloral Hydrate
  • Chlordiazepoxide
  • Chlorpromazine
  • Chlorzoxazone
  • Clarithromycin
  • Clobazam
  • Clonazepam
  • Clorazepate
  • Clozapine
  • Codeine
  • Conivaptan
  • Cyclobenzaprine
  • Dexmedetomidine
  • Diacetylmorphine
  • Diazepam
  • Dichloralphenazone
  • Difenoxin
  • Dihydrocodeine
  • Diphenhydramine
  • Diphenoxylate
  • Doxylamine
  • Droperidol
  • Enflurane
  • Estazolam
  • Eszopiclone
  • Ethchlorvynol
  • Ethopropazine
  • Ethylmorphine
  • Fentanyl
  • Fluphenazine
  • Flurazepam
  • Fluspirilene
  • Fosaprepitant
  • Fospropofol
  • Halazepam
  • Haloperidol
  • Halothane
  • Hexobarbital
  • Hydrocodone
  • Hydromorphone
  • Hydroxyzine
  • Idelalisib
  • Imatinib
  • Indinavir
  • Isoflurane
  • Ketamine
  • Ketazolam
  • Ketobemidone
  • Levorphanol
  • Lorazepam
  • Loxapine
  • Meclizine
  • Melperone
  • Meperidine
  • Meprobamate
  • Meptazinol
  • Mesoridazine
  • Metaxalone
  • Methadone
  • Methdilazine
  • Methocarbamol
  • Methotrimeprazine
  • Methylene Blue
  • Midazolam
  • Molindone
  • Moricizine
  • Morphine
  • Morphine Sulfate Liposome
  • Nalbuphine
  • Nefazodone
  • Nicomorphine
  • Nilotinib
  • Nitrazepam
  • Nitrous Oxide
  • Olanzapine
  • Opium
  • Opium Alkaloids
  • Orphenadrine
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • Papaveretum
  • Paregoric
  • Pentazocine
  • Perampanel
  • Perazine
  • Periciazine
  • Perphenazine
  • Pimozide
  • Piperacetazine
  • Pipotiazine
  • Piritramide
  • Prazepam
  • Primidone
  • Prochlorperazine
  • Promazine
  • Promethazine
  • Propofol
  • Quazepam
  • Quetiapine
  • Ramelteon
  • Remifentanil
  • Remoxipride
  • Sertindole
  • Sodium Oxybate
  • Sufentanil
  • Sulpiride
  • Tapentadol
  • Telithromycin
  • Temazepam
  • Thiethylperazine
  • Thiopropazate
  • Thioridazine
  • Tilidine
  • Tizanidine
  • Tolonium Chloride
  • Topiramate
  • Tramadol
  • Triazolam
  • Trifluoperazine
  • Trifluperidol
  • Triflupromazine
  • Trimeprazine
  • Voriconazole
  • Zaleplon
  • Zolpidem
  • Zopiclone
  • Zotepine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of suvorexant. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse, history of or
  • Drug abuse, history of—Dependence on suvorexant may be more likely to develop.
  • Breathing or lung problems (eg, COPD, sleep apnea) or
  • Cataplexy (sudden onset of muscle weakness), history of or
  • Depression, history of or
  • Mental illness, history of—Use with caution. May make these conditions worse.
  • Narcolepsy (uncontrollable desire for sleep or a sudden attack of deep sleep)—Should not be used in patients with this condition.
  • Obese patients (especially in obese women)—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of suvorexant

Take suvorexant only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much is taken, it may become habit-forming (causing mental or physical dependence).

suvorexant should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Take suvorexant within 30 minutes before going to bed, when you are ready to go to sleep. suvorexant works very quickly to put you to sleep.

suvorexant should not be taken with food or right after a meal. It will work faster if you take it on an empty stomach. However, if your doctor tells you to take the medicine a certain way, take it exactly as directed.

Do not take suvorexant when your schedule does not permit you to get a full night's sleep (at least 7 hours). If you must wake up before this, you may continue to feel drowsy and may experience memory problems, because the effects of the medicine have not had time to wear off.

Do not eat grapefruit or drink grapefruit juice while you are using suvorexant.


The dose of suvorexant will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of suvorexant. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For treatment of insomnia:
      • Adults—10 milligrams (mg) at bedtime. Your doctor may increase your dose as needed. However, the dose is usually not more than 20 mg per day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of suvorexant, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Use suvorexant only when you cannot sleep. You do not need to keep a regular schedule for taking it.


Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Protect the tablets from moisture and do not remove from the blister pack until you are ready to use them.

Precautions While Using suvorexant

It is very important that your doctor check your progress at regular visits to make sure suvorexant is working properly and to check for unwanted effects.

If you think you need to take suvorexant for more than 7 to 10 days, be sure to discuss it with your doctor. Insomnia that lasts longer than this may be a sign of another medical problem.

suvorexant will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds, sedatives, tranquilizers, or sleeping medicine, prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using suvorexant.

suvorexant may cause some people to become drowsy or less alert than they are normally. Even though suvorexant is taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to suvorexant before you drive, use machines, or do anything else that could be dangerous if you are not alert.

If you develop any unusual and strange thoughts or behavior while you are taking suvorexant, be sure to discuss it with your doctor. Some changes that have occurred in people taking suvorexant are like those seen in people who drink alcohol and then act in a manner that is not normal. Other changes may be more unusual and extreme, such as confusion, worsening of depression, hallucinations (seeing, hearing, or feeling things that are not there), suicidal thoughts, and unusual excitement, nervousness, or irritability.

suvorexant may cause you to do things while you are still asleep that you may not remember the next morning. You could drive a car, sleepwalk, have sex, make phone calls, or prepare and eat food while you are asleep or not fully awake. Tell your doctor right away if any of these things occur.

suvorexant may cause sleep paralysis (temporary inability to move or talk for up to several minutes while you are going to sleep or wake up) or have cataplexy-like symptoms (temporary weakness in your legs). Tell your doctor right away if you have these symptoms while you are using suvorexant.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

suvorexant Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
  • Sleepiness or unusual drowsiness
Less common
  • Unusual or abnormal dreams
Incidence not known
  • Changes in behavior
  • discouragement
  • fear or nervousness
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • loss of memory
  • problems with memory
  • seeing, hearing, or feeling things that are not there
  • temporary inability to move or talk for up to several minutes while you are going to sleep or wake up
  • temporary weakness in your legs
  • thoughts of killing oneself
  • tiredness
  • trouble concentrating

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Headache
Less common
  • Body aches or pain
  • chills
  • cough
  • diarrhea
  • difficulty with breathing
  • dizziness
  • dry mouth
  • ear congestion
  • fever
  • loss of voice
  • nasal congestion
  • runny nose
  • sneezing
  • sore throat
  • unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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