Sevoflurane Dosage
Applies to the following strengths: 100%
Usual Adult Dose for:
Usual Geriatric Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Anesthesia
Surgical levels of anesthesia can usually be achieved with inspired concentrations of 0.5 to 3% sevoflurane with or without the concomitant use of nitrous oxide.
Average MAC (minimum alveolar concentration) with sevoflurane in oxygen:
- 25 year old: 2.6%
- 40 year old: 2.1%
- 60 year old: 1.7%
Average MAC with sevoflurane in 65% N2O/35% O2:
- 25 year old: 1.4%
- 40 year old: 1.1%
- 60 year old: 0.9%
Comments:
- Know the concentration delivered from a vaporizer during anesthesia; use a vaporizer calibrated specifically for sevoflurane.
- Individualize and titrate dose to the desired effect according to the patient's age and clinical status.
- Premedicate according to patient needs, at the discretion of the anesthesiologist.
- Suitable for mask induction as it has a nonpungent odor and does not cause respiratory irritability.
Use: Induction and maintenance of general anesthesia for inpatient and outpatient surgery
Usual Geriatric Dose for Anesthesia
Surgical levels of anesthesia can usually be achieved with inspired concentrations of 0.5 to 3% sevoflurane with or without the concomitant use of nitrous oxide.
Average MAC (minimum alveolar concentration) with sevoflurane in oxygen:
- 80 year old: 1.4%
Average MAC with sevoflurane in 65% N2O/35% O2:
- 80 year old: 0.7%
Comments:
- MAC decreases with increasing age; the average concentration of sevoflurane to achieve MAC in an 80 year old is approximately 50% of that required in a 20 year old.
- Know the concentration delivered from a vaporizer during anesthesia; use a vaporizer calibrated specifically for sevoflurane.
- Individualize and titrate dose to the desired effect according to the patient's age and clinical status.
- Premedicate according to patient needs, at the discretion of the anesthesiologist.
- Suitable for mask induction as it has a nonpungent odor and does not cause respiratory irritability.
Use: Induction and maintenance of general anesthesia for inpatient and outpatient surgery
Usual Pediatric Dose for Anesthesia
Surgical levels of anesthesia can usually be achieved with inspired concentrations of 0.5 to 3% sevoflurane with or without the concomitant use of nitrous oxide.
Average MAC (minimum alveolar concentration) with sevoflurane in oxygen:
- 0 to 1 month: 3.3%
- 1 to less than 6 months: 3%
- 6 months to less than 3 years: 2.8%
- 3 to 12 years: 2.5%
Average MAC with sevoflurane in 60% N2O/40% O2:
- 6 months to less than 3 years: 2%
Comments:
- The concentration required for maintenance of general anesthesia is age dependent.
- When used in combination with nitrous oxide, reduce the MAC equivalent dose.
- MAC in premature infants has not been determined.
- Know the concentration delivered from a vaporizer during anesthesia; use a vaporizer calibrated specifically for sevoflurane.
- Individualize and titrate dose to the desired effect according to the patient's age and clinical status.
- Premedicate according to patient needs, at the discretion of the anesthesiologist.
- Suitable for mask induction as it has a nonpungent odor and does not cause respiratory irritability.
Use: Induction and maintenance of general anesthesia for inpatient and outpatient surgery
Renal Dose Adjustments
Use with caution.
Liver Dose Adjustments
Use with caution.
Dose Adjustments
- The anesthetic requirement for sevoflurane is decreased when administered in combination with nitrous oxide.
- Using 50% N2O, the MAC equivalent dose requirement is reduced approximately 50% in adults, and approximately 25% in pediatric patients.
Dialysis
Data not available
Other Comments
Administration advice:
- Administer only by persons trained in the administration of general anesthesia.
- Facilities for maintenance of a patent airway, artificial ventilation, oxygen enrichment, and circulatory resuscitation must be immediately available.
- Since level of anesthesia may be altered rapidly, only vaporizers producing predictable concentrations of sevoflurane should be used.
General:
- Replace CO2 absorbent for suspicion of desiccation.
Occupational Caution:
- There is no specific work exposure limit established for sevoflurane.
- The National Institute for Occupational Safety and Health recommends an 8 hour time-weighted average limit of 2 ppm for halogenated anesthetic agents in general (0.5 ppm when coupled with exposure to N2O)
More about sevoflurane
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- During pregnancy
- Drug class: general anesthetics
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