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Sevoflurane Side Effects

In Summary

More frequently reported side effects include: tachycardia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to sevoflurane: inhalation liquid

Along with its needed effects, sevoflurane may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. While you are receiving and recovering from an inhalation anesthetic like sevoflurane, your health care professional will closely follow its effects. However, some effects may not be noticed until later.

Some side effects of sevoflurane may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Less common

For Healthcare Professionals

Applies to sevoflurane: inhalation liquid


The most common adverse events were nausea, vomiting, hypotension, agitation, and cough.[Ref]


Very common (10% or more): Nausea (25%), vomiting (18%)
Common (1% to 10%): Increased salivation
Uncommon (0.1% to 1%): Dry mouth[Ref]


Very common (10% or more): Hypotension (11%), bradycardia
Common (1% to 10%): Tachycardia, hypertension
Uncommon (0.1% to 1%): Arrhythmia, ventricular extrasystoles, supraventricular extrasystoles, complete AV block, bigeminy, inverted T wave, atrial fibrillation, atrial arrhythmia, second degree AV block, S-T depressed, extrasystoles
Frequency not reported: QT prolongation, torsade de pointes
Postmarketing reports: Cardiac arrest[Ref]


Very common (10% or more): Cough increased (11%),
Common (1% to 10%): Laryngospasm, airway obstruction, breath holding, apnea, respiratory disorder
Uncommon (0.1% to 1%): Sputum increased, hypoxia, wheezing, bronchospasm, hyperventilation, pharyngitis, hiccup, hypoventilation, dyspnea, stridor, hypoxia, asthma
Postmarketing reports: Pulmonary edema[Ref]


Very common (10% or more): Agitation (up to 15%)
Uncommon (0.1% to 1%): Crying, nervousness, confusion, insomnia, confusional state[Ref]

Nervous system

Common (1% to 10%): Somnolence, dizziness, movement
Uncommon (0.1% to 1%): Syncope, hypertonia, taste perversion
Postmarketing reports: Seizures, dystonia[Ref]


Common (1% to 10%): Shivering, fever, hypothermia, headache, blood fluoride increased
Uncommon (0.1% to 1%): Asthenia, pain, fluorosis,
Rare (less than 0.1%): Malignant hyperthermia[Ref]


Common (1% to 10%): White blood cell count abnormal
Uncommon (0.1% to 1%): Hemorrhage, leukocytosis, thrombocytopenia, leukopenia
Postmarketing reports: Transient elevations in white blood cell count[Ref]


Common (1% to 10%): Liver function test abnormal
Uncommon (0.1% to 1%): Increases in AST, increases in ALT, bilirubinemia
Postmarketing reports: Hepatic dysfunction, hepatitis, jaundice, hepatic necrosis, hepatic failure, transient elevations in liver function tests[Ref]


Common (1% to 10%): Blood glucose abnormal
Uncommon (0.1% to 1%): Increases in LDH, increases in alkaline phosphatase, hypophosphatemia, acidosis, hyperglycemia
Postmarketing reports: Transient elevations in glucose[Ref]


Uncommon (0.1% to 1%): Increases in BUN, increases in creatinine, glycosuria, albuminuria,
Frequency not reported: Mild impairment of renal concentrating ability
Postmarketing reports: Acute renal failure[Ref]


Uncommon (0.1% to 1%): Amblyopia, conjunctivitis[Ref]


Uncommon (0.1% to 1%): Urination impaired, urine abnormality, urinary retention, oliguria[Ref]


Uncommon (0.1% to 1%): Pruritus, rash[Ref]


Postmarketing reports: Allergic reactions, urticaria, bronchospasm, anaphylactic or anaphylactoid reaction, hypersensitivity (including contact dermatitis, rash, dyspnea, wheezing, chest discomfort, swelling face, or anaphylactic reaction)[Ref]


Postmarketing reports: Muscle twitching[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Ultane (sevoflurane)." Abbott Pharmaceutical, Abbott Park, IL.

Some side effects of sevoflurane may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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