Roweepra XR Dosage
Medically reviewed by Drugs.com. Last updated on Nov 11, 2020.
2.1 Recommended Dosing
ROWEEPRA XR is administered once daily.
Initiate treatment with a dose of 1,000 mg once daily. The once daily dosage may be adjusted in increments of 1,000 mg every 2 weeks to a maximum recommended daily dose of 3,000 mg/day.
2.2 Dosage Adjustment in Adult Patients with Renal Impairment
ROWEEPRA XR dosing must be individualized according to the patient's renal function status.
Recommended dosage adjustments for adults are shown in Table 1. In order to calculate the dose recommended for patients with renal impairment, creatinine clearance adjusted for body surface area must be calculated. To do this, an estimate of the patient's creatinine clearance (CLcr) in mL/min must first be calculated using the following formula:
[140-age (years)] x weight (kg)
CLcr=--------------------------------------- (x 0.85 for female patients)
72 x serum creatinine (mg/dL)
Then CLcr is adjusted for body surface area (BSA) as follows:
CLcr(mL/min/1.73m 2 )=--------------- x 1.73
BSA subject (m 2 )
(mL/min/1.73m 2 )
|Normal||> 80||1,000 to
|Every 24 hours|
|Mild||50 - 80||1,000 to
|Every 24 hours|
|Moderate||30 - 50||500 to 1,500||Every 24 hours|
|Severe||<30||500 to 1,000||Every 24 hours|
More about Roweepra XR (levetiracetam)
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- Drug class: pyrrolidine anticonvulsants
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