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Roflumilast Dosage

Medically reviewed by Last updated on Apr 1, 2024.

Applies to the following strengths: 250 mcg; 500 mcg

Usual Adult Dose for Chronic Obstructive Pulmonary Disease - Maintenance

Initial dose: 250 mcg orally once a day for 4 weeks
Maintenance dose: 500 mcg orally once a day


Use(s): To reduce the risk of COPD exacerbations in patients with severe COPD associated with chronic bronchitis and a history of exacerbations.

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Contraindicated in moderate to severe liver impairment (Child-Pugh B or C)



Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments


Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.