Inpefa Dosage

Prior to Initiation of INPEFA

Assess volume status and, if necessary, correct volume depletion prior to initiation of INPEFA.

Assess renal function prior to initiation of INPEFA and then as clinically indicated.

For patients with decompensated heart failure, dosing may begin as soon as the patient is hemodynamically stable, including during hospitalization or urgent outpatient treatment or immediately upon discharge.

Recommended Dosage

The recommended starting dose of INPEFA is 200 mg orally once daily not more than one hour before the first meal of the day.

Up-titrate after at least 2 weeks to 400 mg orally once daily as tolerated. Down-titrate to 200 mg as necessary.

Swallow tablets whole. Do not cut, crush, or chew tablets.

If a dose of INPEFA is missed by more than 6 hours, take the next dose as prescribed the next day.

Temporary Interruption for Surgery

Withhold INPEFA at least 3 days, if possible, prior to major surgery or procedures associated with prolonged fasting. Resume INPEFA when the patient is clinically stable and has resumed oral intake.