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Ibrexafungerp Dosage

Medically reviewed by Drugs.com. Last updated on Aug 3, 2021.

Applies to the following strengths: 150 mg

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Vaginal Candidiasis

300 mg orally twice a day for 1 day

Comments:

  • Doses should be administered about 12 hours apart (e.g., in the morning and in the evening).
  • The total treatment dosage is 600 mg.

Use: For the treatment of adult females with vulvovaginal candidiasis

Usual Pediatric Dose for Vaginal Candidiasis

Postmenarchal females: 300 mg orally twice a day for 1 day

Comments:

  • Doses should be administered about 12 hours apart (e.g., in the morning and in the evening).
  • The total treatment dosage is 600 mg.

Use: For the treatment of postmenarchal pediatric females with vulvovaginal candidiasis

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Concomitant use of a strong CYP450 3A inhibitor: 150 mg orally twice a day for 1 day

Comments:

  • Doses should be administered about 12 hours apart (e.g., in the morning and in the evening).
  • No dosage adjustment needed with concomitant use of a weak or moderate CYP450 3A inhibitor.

Precautions

CONTRAINDICATIONS:
Pregnancy; hypersensitivity to the active component

Safety and efficacy have not been established in premenarchal pediatric females.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

Before starting this drug, verify pregnancy status in patients of childbearing potential.May administer with or without foodAdminister doses about 12 hours apart (e.g., in the morning and in the evening) for 1 day.If the first dose is administered in the morning, administer the second dose that same day in the evening.If the first dose is administered in the afternoon or evening, administer the second dose the following morning.

Storage requirements:
  • Store at 20C to 25C (68F to 77F); brief exposure to 15C to 30C (59F to 86F) permitted.

General:
  • If specimens for fungal culture are obtained before therapy, antifungal therapy may be started before results are known; antifungal therapy should be adjusted accordingly when results are available.

Monitoring:
  • General: For pregnancy (before starting therapy)

Patient advice:
  • Read the US FDA-approved patient labeling (Patient Information).
  • Notify health care provider of known/suspected pregnancy; if you inadvertently took this drug during pregnancy, you are encouraged to report it by calling 1-888-982-7299.
  • Patients of childbearing potential: Use effective contraception while taking this drug and for 4 days after the last dose.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.