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Hydrochlorothiazide / Valsartan Dosage

Medically reviewed by Drugs.com. Last updated on Feb 5, 2024.

Applies to the following strengths: 12.5 mg-80 mg; 12.5 mg-160 mg; 25 mg-160 mg; 12.5 mg-320 mg; 25 mg-320 mg

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Initial dose: 1 tablet (12.5 mg-160 mg) orally once a day

Maintenance dose: Titrate as necessary (every 1 to 2 weeks) up to a maximum of 25 mg-320 mg orally once a day

Comment:

Renal Dose Adjustments

CrCl less than 30 mL/min: Hydrochlorothiazide-valsartan is not recommended because hydrochlorothiazide is not expected to be filtered into the renal tubule (its site of action) when the glomerular filtration rate is less than 30 mL/min.

Liver Dose Adjustments

Because valsartan is primarily eliminated by the liver, caution is recommended when advancing doses or giving maximum doses to a patient with liver disease. Theoretically, the risk of side effects is higher in this case, especially when higher doses are used.

Precautions

US BOXED WARNINGS:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Valsartan is not removed by hemodialysis.

Other Comments

Administration advice:


General:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.