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Glyburide / Metformin Dosage

Medically reviewed by Last updated on Aug 11, 2023.

Applies to the following strengths: 1.25 mg-250 mg; 2.5 mg-500 mg; 5 mg-500 mg

Usual Adult Dose for Diabetes Type 2

Doses provided as glyburide-metformin

Starting dose: 1.25 mg-250 mg orally once a day
Maintenance Dose: Increase in increments of 1.25 mg-250 mg per day every 2 weeks up to the minimum effective dose to achieve glycemic control
Maximum Initial Dose: 10 mg-2000 mg per day

Initial dose: 2.5 mg-500 mg or 5 mg-500 mg orally twice a day
Maintenance Dose: Increase in increments of no more than 5 mg-500 mg to the minimum effective dose to achieve adequate blood glucose control
Maximum Dose: 20 mg-2000 mg per day


Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Renal Dose Adjustments

New Metformin Renal Dosing: Obtain eGFR prior to initiating therapy:


Liver Dose Adjustments

Not recommended in patients with clinical or laboratory evidence of hepatic disease.

Dose Adjustments

Elderly, debilitated, and malnourished patients should generally not be titrated to the maximum dose to avoid the risk of hypoglycemia

Temporarily stop treatment prior to radiologic studies utilizing iodinated contrast materials and for surgical procedures when restricted food or fluid intake is expected; may resume once adequate renal function is confirmed

Concomitant Thiazolidinedione Use:

Concomitant Use with Colesevelam:



Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


No data available.

Other Comments

Administration advice:


Renal: Assess renal function baseline, repeat at least annually and more often as clinically indicated.
Hematologic: Measure hematologic parameters annually
Monitor glycemic control: Periodic fasting blood glucose and HbA1c

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.