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Cefamandole Dosage

Applies to the following strengths: 1 g; 2 g; 10 g

Usual Adult Dose for Pneumonia

500 mg intramuscularly or IV every 6 hours.

Usual Adult Dose for Skin or Soft Tissue Infection

500 mg intramuscularly or IV every 6 hours.

Usual Adult Dose for Urinary Tract Infection

Uncomplicated: 500 mg intramuscularly or IV every 8 hours.
Complicated: 1 g intramuscularly or IV every 8 hours.

Usual Adult Dose for Surgical Prophylaxis

Preoperative: 1 to 2 g IV or intramuscularly 30 to 60 minutes prior to surgical incision.
Postoperative: 1 to 2 g IV or intramuscularly every 6 hours for 24 to 48 hours (72 hours for prosthetic arthroplasty).
Cesarean section: the initial dose may be administered just prior to surgery or immediately after the cord is clamped.

Usual Pediatric Dose for Surgical Prophylaxis

> 3 months:
50 to 100 mg/kg/day in divided doses IV or intramuscularly 30 to 60 minutes prior to surgical incision and every 6 hours for 24 to 48 hours.

Renal Dose Adjustments

CrCl < 2 mL/min:
After initial dose of 1 to 2 g, 0.25 to 0.5 g IV or intramuscularly every 12 hours. Maximum dose 0.5 g IV or intramuscularly every 8 hours or 0.75 g IV or intramuscularly every 12 hours.

CrCl 2 to 10 mL/min: After initial dose of 1 to 2 g, 0.5 to 0.75 g IV or intramuscularly every 12 hours. Maximum dose 0.67 g IV or intramuscularly every 8 hours or 1 g IV or intramuscularly every 12 hours.

CrCl 10 to 25 mL/min: After initial dose of 1 to 2 g, 0.5 to 1 g IV or intramuscularly every 8 hours. Maximum dose 1 g IV or intramuscularly every 6 hours or 1.25 g IV or intramuscularly every 8 hours.

CrCl 25 to 50 mL/min: After initial dose of 1 to 2 g, 0.75 to 1.5 g IV or intramuscularly every 8 hours. Maximum dose 1.5 g IV or intramuscularly every 6 hours or 2 g IV or intramuscularly every 8 hours.

CrCl 50 to 80 mL/min: After initial dose of 1 to 2 g, 0.75 to 1.5 g IV or intramuscularly every 6 hours. Maximum dose 1.5 g IV or intramuscularly every 4 hours or 2 g IV or intramuscularly every 6 hours.

Liver Dose Adjustments

No adjustment recommended

Dialysis

Hemodialysis may be considered in cases of overwhelming overdosage.

Other Comments

Treatment should be continued for a minimum of 48 to 72 hours after the patient becomes asymptomatic or after evidence of bacterial eradication has been obtained. A minimum of 10 days of treatment is recommended in infections caused by group A beta-hemolytic streptococci in order to guard against the risk of rheumatic fever or glomerulonephritis.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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