Cefamandole Dosage

Usual Adult Dose for Pneumonia

500 mg intramuscularly or IV every 6 hours.

Usual Adult Dose for Skin or Soft Tissue Infection

500 mg intramuscularly or IV every 6 hours.

Usual Adult Dose for Urinary Tract Infection

Uncomplicated: 500 mg intramuscularly or IV every 8 hours.
Complicated: 1 g intramuscularly or IV every 8 hours.

Usual Adult Dose for Surgical Prophylaxis

Preoperative: 1 to 2 g IV or intramuscularly 30 to 60 minutes prior to surgical incision.
Postoperative: 1 to 2 g IV or intramuscularly every 6 hours for 24 to 48 hours (72 hours for prosthetic arthroplasty).
Cesarean section: the initial dose may be administered just prior to surgery or immediately after the cord is clamped.

Usual Pediatric Dose for Surgical Prophylaxis

> 3 months:
50 to 100 mg/kg/day in divided doses IV or intramuscularly 30 to 60 minutes prior to surgical incision and every 6 hours for 24 to 48 hours.

Renal Dose Adjustments

CrCl < 2 mL/min:
After initial dose of 1 to 2 g, 0.25 to 0.5 g IV or intramuscularly every 12 hours. Maximum dose 0.5 g IV or intramuscularly every 8 hours or 0.75 g IV or intramuscularly every 12 hours.

CrCl 2 to 10 mL/min: After initial dose of 1 to 2 g, 0.5 to 0.75 g IV or intramuscularly every 12 hours. Maximum dose 0.67 g IV or intramuscularly every 8 hours or 1 g IV or intramuscularly every 12 hours.

CrCl 10 to 25 mL/min: After initial dose of 1 to 2 g, 0.5 to 1 g IV or intramuscularly every 8 hours. Maximum dose 1 g IV or intramuscularly every 6 hours or 1.25 g IV or intramuscularly every 8 hours.

CrCl 25 to 50 mL/min: After initial dose of 1 to 2 g, 0.75 to 1.5 g IV or intramuscularly every 8 hours. Maximum dose 1.5 g IV or intramuscularly every 6 hours or 2 g IV or intramuscularly every 8 hours.

CrCl 50 to 80 mL/min: After initial dose of 1 to 2 g, 0.75 to 1.5 g IV or intramuscularly every 6 hours. Maximum dose 1.5 g IV or intramuscularly every 4 hours or 2 g IV or intramuscularly every 6 hours.

Liver Dose Adjustments

No adjustment recommended

Dialysis

Hemodialysis may be considered in cases of overwhelming overdosage.

Other Comments

Treatment should be continued for a minimum of 48 to 72 hours after the patient becomes asymptomatic or after evidence of bacterial eradication has been obtained. A minimum of 10 days of treatment is recommended in infections caused by group A beta-hemolytic streptococci in order to guard against the risk of rheumatic fever or glomerulonephritis.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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