Medically reviewed by Drugs.com. Last updated on Aug 21, 2020.
Applies to the following strengths: 20 mg; 10 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Initial dose: 10 mg orally once a day
Dose titration: If desired response is not achieved after 1 to 2 weeks, dose may be doubled.
Maximum dose: 40 mg per day
-Doses greater than 20 mg once a day did not result in significant additional antihypertensive effects; however, the 40 mg dose has been studied and was well tolerated.
Use: Management of hypertension alone or with another antihypertensive agent, especially thiazide diuretics
Renal Dose Adjustments
Mild to moderate renal impairment: No adjustment recommended
Severe renal impairment: Initial dose: 5 mg orally once a day; may increase in 5 mg increments every 2 weeks as needed to a maximum dose of 20 mg orally once a day.
Liver Dose Adjustments
No adjustment recommended.
-Use not recommended
-However, if use is necessary, use the lowest possible dose and ensure a bronchodilator is available.
-For doses over 10 mg, consider dividing dosage to avoid higher peak blood levels associated with once a day dosing.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
-Initial dose: 5 mg orally once a day
-If response not achieved, increase dose in 5 mg increments every 2 weeks.
-Maximum dose: 20 mg/day
Peritoneal dialysis: This drug is dialyzable; however, no dose adjustment guidelines have been provided.
-If a dose is missed, take it as soon as remembered; if it is close to the next dose, skip the missed dose; do not double the dose.
-If discontinuation is necessary, gradually taper over 2 weeks, monitor for the signs and symptoms of heart failure and limit exercise.
-Monitor patients taking concurrent ophthalmic beta-blocker solutions for additive effects (e.g., bradycardia, reduced intraocular pressure, and hypotension).
-Inform physicians, ophthalmologists, and dentists when using this drug, especially if surgery is planned.
-This drug interferes with allergic reaction modulation and may increase the risk of anaphylactic reactions; additionally, patients may be refractory to epinephrine in treatment for anaphylactic reactions.
-Heart rate and blood pressure
-Signs and symptoms of heart failure (e.g., shortness of breath, edema, and weight gain), especially in at risk patients
-Signs and symptoms of angina in patients with coronary heart disease, especially during withdrawal
-Warn patients to avoid interruptions or abrupt discontinuation of this drug.
-Instruct patients to notify their healthcare provider upon signs and symptoms of angina, bradycardia, hypotension, or heart failure (e.g., shortness of breath, edema, and weight gain).
-Avoid driving or operating machinery until the full effects are known.
-Advise patient to speak to healthcare provider if pregnant, intend to become pregnant, or are breastfeeding.
-Patients with diabetes should be informed that this drug may mask hypoglycemic reactions.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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- Drug class: cardioselective beta blockers
Other brands: Kerlone