Aurothioglucose Dosage

Usual Adult Dose for Rheumatoid Arthritis

10 mg IM one time as a test dose.
Observe for 15-30 minutes for adverse/allergic reaction.
25 mg IM one week later and repeat in another week.
50 mg IM once a week until a cumulative dose of 0.8 to 1 G has been reached. If a clinical response has been documented, the dosage may be reduced to a maintenance dosage of 50 mg intramuscularly every three to four weeks. This maintenance dosage may be continued indefinitely based on this patient's response to and tolerance of aurothioglucose.

Usual Pediatric Dose for Rheumatoid Arthritis

Child 6-12 years:
0.25 mg/kg one time as a test dose.
Observe for 15-30 minutes for adverse/allergic reaction.
Increase at 0.25 mg/kg/dose with each weekly dose.
Maintenance dose: 0.75-1 mg/kg/dose (Max 25 mg) weekly to a total of 20 doses. Then give dose every 3-4 weeks.

Dose Adjustments

If a clinical response has been noted, the dose may be reduced to 50 mg IM once every other week for 1-2 months. If the response persists, the dose should be further reduced to a maintenance dose of 50 mg IM every 3-4 weeks. The maintenance dose may be continued indefinitely based on the patient response to and tolerance of aurothioglucose. If a clinical response has been noted, the dose may be reduced to 50 mg IM once every other week for 1-2 months. If the response persists, the dose should be further reduced to a maintenance dose of 50 mg IM every 3-4 weeks. The maintenance dose may be continued indefinitely based on the patient response to and tolerance of aurothioglucose.

Precautions

Aurothioglucose is contraindicated in patients with renal dysfunction. Prior to initiation of therapy, a CBC with differential, platelet count, urinalysis, renal and liver function tests should be performed. Thereafter, a CBC with differential, platelet count, and urinalysis should be done prior to each injection.

Other Comments

If no response is noted after 1000-1200 mg, alternative therapy should be considered.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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