Amlodipine / Telmisartan Dosage
Applies to the following strength(s): 5 mg-40 mg ; 10 mg-40 mg ; 5 mg-80 mg ; 10 mg-80 mg
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Amlodipine 5 to 10 mg-Telmisartan 40 to 80 mg orally once a day
Maximum dose: Amlodipine 10 mg-Telmisartan 80 mg orally once a day
-Correct volume and salt depletion before initiating therapy.
-Dose titration with the individual components is recommended before switching to this drug; treatment may be initiated with this drug if it is unlikely that blood pressure would be controlled with monotherapy; the usual starting dose for treatment initiation is amlodipine 5 mg-telmisartan 40 mg once a day.
-Patients who experience any dose limiting adverse reactions with amlodipine 10 mg monotherapy may be switched to amlodipine 5 mg-telmisartan 40 mg once a day to reduce the amlodipine dose without reducing the overall expected antihypertensive response.
-Start with a low initial amlodipine dose in patients 65 years or older; initial therapy with this drug is not recommended in patients 75 years or older.
-May increase dose after 2 weeks.
Renal Dose Adjustments
Mild to moderate renal dysfunction: No adjustment recommended
Severe renal dysfunction: Titrate slowly
Liver Dose Adjustments
Liver dysfunction: Not recommended for initial therapy
Biliary obstructive disorder: Initiate at low doses and titrate slowly
US BOXED WARNING:
-FETAL TOXICITY: If pregnancy is detected, discontinue this drug as soon as possible. Drugs that act directly on the renin-angiotensin system (RAS) can cause injury and death to the developing fetus.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available
Administration advice: May take with or without food.
General: Telmisartan plasma concentrations are generally 2 to 3 times higher in females; however, in clinical trials, no significant increases in blood pressure response or orthostatic hypotension were found in women.
Monitoring: Closely monitor patients with heart failure or biliary obstructive disorders who are taking this drug.
-Females of childbearing age should be informed of the consequences of exposure to this drug during pregnancy; ask these patients to report pregnancies as soon as possible.
-Advise patients to immediately report any signs or symptoms of angioedema (breathing difficulty or swelling of face, eyes, lips, or tongue) and to stop taking this drug until consulting a physician.
-Encourage patients to report any lightheadedness that may occur during treatment initiation and to stop taking this drug until consulting a physician if syncope occurs.
-Dehydration may lead to excess blood pressure reduction; inform patients to contact their healthcare provider if they experience excessive perspiration, vomiting, or diarrhea.
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Other brands: Twynsta