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Acetaminophen / Caffeine / Isometheptene Mucate Dosage

Applies to the following strengths: 325 mg-20 mg-65 mg; 500 mg-20 mg-130 mg; 325 mg-100 mg-65 mg

The information at is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Headache

Migraine headache: 2 capsules or caplets at once orally, followed by one capsule or caplet every hour until relieved, up to 5 capsules or caplets within a 12 hour period

Tension headache: 1 to 2 capsules or caplets every 4 hours, up to 8 capsules or caplets a day

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Use with caution in patients with mild or moderated liver disease. Chronic use of acetaminophen is not recommended in patients with liver disease.


Contraindicated in patients with severe renal or hepatic dysfunction.

Patients who consume three or more alcohol containing drinks per day should be informed to consult with their physician for advice on when and how to take acetaminophen. Chronic, heavy alcohol users may be at increased risk of liver damage when taking more than recommended dosages.

Caffeine is a central nervous system stimulant and in cases of caffeine overdose, seizures have been reported.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).


Data not available

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.