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Acetaminophen / Caffeine / Isometheptene Mucate Dosage

Applies to the following strengths: 325 mg-20 mg-65 mg; 500 mg-20 mg-130 mg; 325 mg-100 mg-65 mg

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Headache

Migraine headache: 2 capsules or caplets at once orally, followed by one capsule or caplet every hour until relieved, up to 5 capsules or caplets within a 12 hour period

Tension headache: 1 to 2 capsules or caplets every 4 hours, up to 8 capsules or caplets a day

Renal Dose Adjustments

Severe renal impairment: Contraindicated

Liver Dose Adjustments

Hepatic disease: Contraindicated



  • Acetaminophen has been associated with cases of acute liver failure at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 mg per day, and often in combination with other acetaminophen-containing products.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.



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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.