Prialt Disease Interactions

The use of ziconotide is contraindicated in patients with any other concomitant treatment or medical condition that would render intrathecal administration hazardous. Contraindications to the use of intrathecal analgesia include the presence of infection at the microinfusion injection site, uncontrolled bleeding diathesis, and spinal canal obstruction that impairs circulation of cerebrospinal fluid.

The use of ziconotide is contraindicated in patients with a preexisting history of psychosis. Severe psychiatric symptoms and neurological impairment may occur during therapy with ziconotide. It is recommended to monitor all patients for evidence of cognitive impairment, hallucinations, or changes in mood or consciousness during treatment with ziconotide. Discontinue therapy with ziconotide in the event of serious neurological or psychiatric signs or symptoms.