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Thyrotropin alpha Disease Interactions

There are 2 disease interactions with thyrotropin alpha.

Moderate

Thyrotropin alfa (applies to thyrotropin alpha) heart disease

Moderate Potential Hazard, Moderate plausibility.

Thyrotropin alfa is known to cause a transient (over 7 to 14 days) but significant rise in serum thyroid hormone concentration when given to patients who have substantial thyroid tissue still in situ or functional thyroid cancer metastases, There have been reports of death in non-thyroidectomized patients and in patients with distant metastatic thyroid cancer in which events leading to death occurred within 24 hours after administration of the drug. Patients with residual thyroid tissue at risk for thyrotropin alfa-induced hyperthyroidism include the elderly and those with a known history of heart disease. Hospitalization for administration of therapy and post-administration observation in patients at risk should be considered.

References

  1. "Product Information. Thyrogen (thyrotropin alfa)." Genzyme Corporation PROD (2001):
Moderate

Thyrotropin alfa (applies to thyrotropin alpha) dialysis

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: hemodialysis

The elimination of thyrotropin alfa is significantly slower in dialysis-dependent end stage renal disease (ESRD) patients, resulting in prolonged elevation of TSH levels.

References

  1. "Product Information. Thyrogen (thyrotropin alfa)." Genzyme Corporation PROD (2001):

Thyrotropin alpha drug interactions

There are 54 drug interactions with thyrotropin alpha.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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